{"id":"W2131339869","doi":"10.1182/blood-2005-04-1550","title":"Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"DMT1; Chinese hamster ovary cell; Exon; Mutation; Biology; Point mutation; Molecular biology; Biochemistry; Genetics; Transporter; Gene; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115768,0.0006039215,0.0002009557,0.0002670972,0.0002665081,0.0002077684,0.0001542388,0.0006786773,0.0009819546],"category_scores_gemma":[0.0003513162,0.000146713,0.0002028459,0.0001459857,0.0005669043,0.0001127657,0.0001805534,0.000445564,0.0002146352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691682,"about_ca_system_score_gemma":0.0001220146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127927,"about_ca_topic_score_gemma":0.0008530518,"domain_scores_codex":[0.9998747,0.00002715644,0.00001484603,0.00003144841,0.00002811156,0.00002360529],"domain_scores_gemma":[0.9998272,0.0000707835,0.0000376109,0.00001298649,0.00001085244,0.00004059943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006445053,0.00007773421,0.0091865,0.00008140557,0.00003338839,0.1317483,0.000211522,0.0004426166,0.8526369,0.0004285516,0.000273318,0.004235291],"study_design_scores_gemma":[0.000151783,0.000688997,0.08003657,0.00002545049,0.0001364949,0.3848609,0.0002057696,0.003490973,0.5257607,0.0006188794,0.003988113,0.0000353049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984321,0.0002173554,0.0004096052,0.0001412901,0.0000120792,0.000007017932,0.0001069065,0.00002300284,0.0006506963],"genre_scores_gemma":[0.9989422,0.0001255285,0.0003644165,0.00004740552,0.000009745753,0.000004496994,0.00009315035,0.000009226935,0.0004039445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127927,"threshold_uncertainty_score":0.003284991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692555519064408,"score_gpt":0.2516387622173834,"score_spread":0.2347132070267393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}