{"id":"W2131339869","doi":"10.1182/blood-2005-04-1550","title":"Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"DMT1; Chinese hamster ovary cell; Exon; Mutation; Biology; Point mutation; Molecular biology; Biochemistry; Genetics; Transporter; Gene; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000730206,0.00006092688,0.00008539746,0.00003084561,0.0000774222,0.000004824383,0.00002830832,0.00004008951,0.0001229498],"category_scores_gemma":[0.00004292258,0.00003772458,0.00002792152,0.00004369596,0.0001133774,0.00003851145,0.00001143624,0.00006642741,0.000006765616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003408357,"about_ca_system_score_gemma":0.00003106145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001367229,"about_ca_topic_score_gemma":0.000004972916,"domain_scores_codex":[0.9994871,0.00002693803,0.0001214685,0.0001078198,0.0001847617,0.00007191669],"domain_scores_gemma":[0.9997594,0.00001118589,0.00006018849,0.0001154553,0.00002469352,0.00002907804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004972136,0.0003835373,0.005794182,0.00007143784,0.000005622604,0.000001759998,0.000263975,0.00001365055,0.9873278,0.00266218,0.0003615007,0.003064696],"study_design_scores_gemma":[0.003838023,0.000154598,0.3118086,0.000125921,0.00009068938,0.00001909125,0.0002631902,0.000003266436,0.6817747,0.0004889338,0.001363642,0.00006924852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952402,0.0003913024,0.00001046919,0.0007582247,0.00003394166,0.0002714053,0.000003674344,0.00001362619,0.00327723],"genre_scores_gemma":[0.998508,0.000007231221,0.000335101,0.0001900795,0.0001021115,0.00001539068,0.000007856699,0.000005365484,0.0008289156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3060144,"threshold_uncertainty_score":0.1538364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692555519064408,"score_gpt":0.2516387622173834,"score_spread":0.2347132070267393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}