{"id":"W2131356514","doi":"","title":"Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CYP2A6; Tranylcypromine; Chemistry; Pharmacology; Hydroxylation; Methoxsalen; Microsome; Dextromethorphan; CYP1A2; Biochemistry; Monoamine oxidase; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004621413,0.0006811084,0.0006368843,0.0002413246,0.0002249476,0.0002766169,0.0002720023,0.0004023958,0.0009034171],"category_scores_gemma":[0.0003651779,0.0002765273,0.0003934298,0.000322128,0.0001324079,0.0002153404,0.0001823826,0.0005514657,0.0004901054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621416,"about_ca_system_score_gemma":0.0002829528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044364,"about_ca_topic_score_gemma":0.002399087,"domain_scores_codex":[0.9994779,0.0001728345,0.00004574503,0.0000818938,0.0001709116,0.00005076238],"domain_scores_gemma":[0.9997173,0.00005922421,0.00006813832,0.00003048023,0.0000826694,0.00004209486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002781367,0.0001217959,0.0002796274,0.0001054754,0.00004239066,0.00004071079,0.00001809888,0.0002005496,0.9941,0.00003978875,0.0001123263,0.004661026],"study_design_scores_gemma":[0.00003089921,0.0012279,0.001735919,0.000004691321,0.00008228074,0.0002760659,0.00001125503,0.0008323394,0.9929224,0.00001100742,0.002859943,0.00000525044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471264,0.02964666,0.01691454,0.0003120908,0.000180858,0.0002621437,0.00155084,0.0002760381,0.003730408],"genre_scores_gemma":[0.9593961,0.01530656,0.01450106,0.0001599465,0.00008832664,0.0002456248,0.004536823,0.00005870444,0.005706997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044364,"threshold_uncertainty_score":0.003022254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1515145333169134,"score_gpt":0.4104899720855356,"score_spread":0.2589754387686222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}