{"id":"W2131375222","doi":"10.1128/mcb.24.10.4255-4266.2004","title":"Characterization of Mouse <i>Rsk4</i> as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences","keywords":"Biology; Ribosomal s6 kinase; Cell biology; MAPK/ERK pathway; Signal transduction; Kinase; Receptor tyrosine kinase; Extracellular; Fibroblast growth factor; Receptor; Genetics; Protein kinase B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001516615,0.0002991165,0.0003872202,0.0001138343,0.0000653777,0.00001359823,0.0002058742,0.0004158913,0.00003550033],"category_scores_gemma":[0.00003217829,0.0002929302,0.0001488124,0.0001356477,0.0002271121,0.00001187699,0.0001123452,0.0001102877,0.000003950493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001016203,"about_ca_system_score_gemma":0.00009783362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000811664,"about_ca_topic_score_gemma":0.000005049196,"domain_scores_codex":[0.9983491,0.0001647576,0.0004891119,0.0005421601,0.0001320202,0.0003228791],"domain_scores_gemma":[0.9989871,0.000006358724,0.0002744827,0.0003842304,0.0001837472,0.0001640719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001279941,0.0001903208,0.0003918994,0.00009000606,0.00007489869,0.00002130327,0.00009836349,0.00004520209,0.9963794,0.002271109,0.000001287273,0.0003082184],"study_design_scores_gemma":[0.00105663,0.001666994,0.000109043,0.00003739392,0.00003631923,0.00001777745,0.00003867881,0.0000187192,0.9959934,0.0004587696,0.000261695,0.0003045495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971736,0.0006350818,0.0270434,0.00002809563,0.00006518326,0.0002808443,0.0001241807,0.0000188432,0.00006838959],"genre_scores_gemma":[0.9974917,0.00005100363,0.0005296873,0.00007447532,0.00008345133,0.00001147588,0.001628895,0.00004469931,0.0000846652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02651371,"threshold_uncertainty_score":0.9999523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005645776628842951,"score_gpt":0.1981594532899964,"score_spread":0.1925136766611535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}