{"id":"W2131447198","doi":"10.1161/hypertensionaha.111.181990","title":"Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase","year":2011,"lang":"en","type":"review","venue":"Hypertension","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"British Heart Foundation; Wellcome Trust","keywords":"Single-nucleotide polymorphism; Locus (genetics); Genetics; Biology; Gene; Promoter; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008157588,0.0009323113,0.002342419,0.001094685,0.0006982646,0.00110408,0.001127139,0.00112229,0.001477266],"category_scores_gemma":[0.0100376,0.0007532491,0.001959133,0.002510533,0.0007991886,0.0004317803,0.0007345914,0.0008056536,0.0002455441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004887508,"about_ca_system_score_gemma":0.0005120775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002811511,"about_ca_topic_score_gemma":0.003428576,"domain_scores_codex":[0.9887112,0.007122747,0.0005796055,0.002527585,0.0008503172,0.0002085084],"domain_scores_gemma":[0.99467,0.002789967,0.0006446026,0.001327224,0.0003630192,0.0002051632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02225778,0.001278902,0.8395886,0.0009384974,0.05632386,0.001568066,0.0004700181,0.001533926,0.03193601,0.002264576,0.002360328,0.03947934],"study_design_scores_gemma":[0.006728281,0.0062562,0.9441651,0.00008153031,0.02235674,0.002742139,0.0001105475,0.007270082,0.003892155,0.00233471,0.003973322,0.00008925237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9519655,0.006988436,0.03619629,0.0003817704,0.0002532521,0.000675742,0.001988509,0.0002276488,0.001322873],"genre_scores_gemma":[0.9727882,0.001268161,0.02236433,0.0003148138,0.0001242917,0.0007740269,0.001624976,0.00004580005,0.0006953926],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.008157588,"threshold_uncertainty_score":0.0431419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042153657417286,"score_gpt":0.2858699989193721,"score_spread":0.1816546331776436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}