{"id":"W2131464323","doi":"10.1002/jlcr.1947","title":"Temperature effects on the stereospecificity of nucleophilic fluorination: formation of <i>trans</i>‐[<sup>18</sup>F]4‐fluoro‐<scp>l</scp>‐proline during the synthesis of <i>cis</i>‐[<sup>18</sup>F]4‐fluoro‐<scp>l</scp>‐proline","year":2011,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences","funders":"","keywords":"Chemistry; Stereospecificity; Diastereomer; Hydrolysis; Nucleophile; Cis–trans isomerism; Walden inversion; Acid hydrolysis; Stereochemistry; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003667002,0.0005214703,0.0002322535,0.000121713,0.0001646324,0.0002683477,0.0002991867,0.0003513989,0.0009197827],"category_scores_gemma":[0.0004631512,0.0002248424,0.000285387,0.00008996927,0.0003927063,0.0003155677,0.0001802051,0.0004204462,0.0003548586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002560284,"about_ca_system_score_gemma":0.0001833119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007470085,"about_ca_topic_score_gemma":0.0009433114,"domain_scores_codex":[0.9997429,0.00006348379,0.00001992805,0.00008012608,0.00004248984,0.00005099461],"domain_scores_gemma":[0.9995856,0.000145905,0.0001342785,0.00004440441,0.00005491345,0.00003495435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001862924,0.000006745264,0.0001140953,0.00003086412,0.00000832501,0.00004493206,0.00004659202,0.00009099233,0.9987971,0.00003314997,0.00001017045,0.0006307487],"study_design_scores_gemma":[0.000003478088,0.00009663618,0.0005174676,0.000001153643,0.000005236188,0.00005974639,0.000006559489,0.0001403283,0.9989545,0.000005783128,0.0002055837,0.000003467272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907491,0.001160344,0.005832433,0.00005467085,0.00001981437,0.0000365,0.0001503072,0.00008749408,0.001909395],"genre_scores_gemma":[0.9970715,0.0003982812,0.001755009,0.00002283215,0.000006500004,0.00001508624,0.0001036303,0.0000396499,0.0005875821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009197827,"threshold_uncertainty_score":0.00307703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251782540682597,"score_gpt":0.2637263998985014,"score_spread":0.2385481458302418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}