{"id":"W2131497592","doi":"10.1038/nm1621","title":"The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers","year":2007,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heart and Stroke Foundation; University of Toronto; University of British Columbia; University Health Network","funders":"","keywords":"Ubiquitin ligase; Biology; Loss of heterozygosity; Cancer research; Tumor suppressor gene; Suppressor; Molecular biology; Carcinogenesis; Cell biology; Cancer; Ubiquitin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190192,0.0004265411,0.0003861819,0.0005778524,0.0004670466,0.0006015403,0.0003343564,0.000499526,0.003316313],"category_scores_gemma":[0.0003607991,0.000238871,0.0002344302,0.0003413292,0.000377535,0.0003172353,0.0005956736,0.0006947781,0.0009775111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006024259,"about_ca_system_score_gemma":0.0003119394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006181131,"about_ca_topic_score_gemma":0.000846129,"domain_scores_codex":[0.9998271,0.00002076962,0.00001027231,0.00003807538,0.00006929509,0.00003454878],"domain_scores_gemma":[0.9998293,0.00001904655,0.00005474162,0.00001553739,0.00002838447,0.00005306676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005473488,0.00003183969,0.003994287,0.000103751,0.00004787705,0.001141214,0.00003145086,0.0003899224,0.9763474,0.001668972,0.001480084,0.01421582],"study_design_scores_gemma":[0.00006238997,0.0001593667,0.03149404,0.00001239403,0.00005615041,0.006383806,0.000105765,0.001534071,0.9231817,0.001043884,0.03595222,0.00001430142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609008,0.01567258,0.01171341,0.002401086,0.0002967679,0.00004785049,0.001565988,0.0005703829,0.006831259],"genre_scores_gemma":[0.987643,0.002297651,0.001986788,0.0001316309,0.0000355429,0.00001066453,0.00105279,0.00003849487,0.006803404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003316313,"threshold_uncertainty_score":0.01109415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318462025037224,"score_gpt":0.304727437300387,"score_spread":0.2915428170500147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}