{"id":"W2131499894","doi":"10.1177/00912700122012706","title":"Pharmacokinetics and Tolerability of GW420867X, a Nonnucleoside Reverse Transcriptase Inhibitor, following Single Escalating Doses in Healthy Male Volunteers","year":2001,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada)","funders":"","keywords":"Pharmacokinetics; Cmax; Pharmacology; Dosing; Tolerability; Medicine; Reverse-transcriptase inhibitor; Adverse effect; Placebo; Human immunodeficiency virus (HIV); Viral load; Immunology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004626702,0.0004254899,0.0005394272,0.0001612199,0.000231217,0.0002853675,0.0001358496,0.0004114839,0.001111274],"category_scores_gemma":[0.0007466224,0.0002969905,0.0001957953,0.0001441614,0.000283445,0.0003071463,0.0001351111,0.0005139712,0.0004100677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001209411,"about_ca_system_score_gemma":0.0001784672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003756061,"about_ca_topic_score_gemma":0.0005101203,"domain_scores_codex":[0.9996904,0.0001357717,0.00001617148,0.00006009389,0.0000654592,0.00003208463],"domain_scores_gemma":[0.9997699,0.00005659273,0.00006695686,0.00002870475,0.00002600991,0.000051922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08207775,0.007893736,0.04837168,0.0003057112,0.0002503448,0.0006599269,0.0007678757,0.001222891,0.7162859,0.0001068116,0.001029038,0.1410282],"study_design_scores_gemma":[0.00731486,0.4392554,0.4593292,0.00002302964,0.000460979,0.002856738,0.0003377021,0.003004187,0.08419496,0.0002254784,0.002922635,0.00007478807],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984425,0.0002895897,0.0005406672,0.0000182185,0.000006356046,0.0001900079,0.0001236951,0.00002594591,0.0003631533],"genre_scores_gemma":[0.9972551,0.0002762926,0.0009847817,0.0000930981,0.00003129977,0.0002240133,0.0002735742,0.00001639888,0.0008455392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111274,"threshold_uncertainty_score":0.003717542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06472534940166322,"score_gpt":0.4050944900719915,"score_spread":0.3403691406703283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}