{"id":"W2131567043","doi":"10.1080/03602530600959615","title":"Evaluation of Which Reactive Metabolite, If Any, Is Responsible for a Specific Idiosyncratic Reaction","year":2006,"lang":"en","type":"review","venue":"Drug Metabolism Reviews","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Metabolite; Reactive intermediate; Circumstantial evidence; Drug reaction; Mechanism (biology); Chemistry; Drug; Pharmacology; Biochemistry; Biology; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006468299,0.0005250343,0.001558661,0.000952926,0.0001664463,0.0006769668,0.0004795836,0.0009103258,0.003995503],"category_scores_gemma":[0.0006306542,0.0001382866,0.0006668726,0.0006638128,0.0002981798,0.0005814473,0.0001968885,0.0005802318,0.002352049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003375112,"about_ca_system_score_gemma":0.0005848439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005847048,"about_ca_topic_score_gemma":0.0009150116,"domain_scores_codex":[0.999744,0.0000721034,0.00002907002,0.00003323518,0.00009828466,0.00002330499],"domain_scores_gemma":[0.9997169,0.000110195,0.00005606293,0.00001264539,0.00008511831,0.0000190617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003719963,0.000140689,0.003085988,0.009890775,0.0001634164,0.002114555,0.00005826225,0.0004340824,0.02907862,0.002580463,0.007699829,0.9443814],"study_design_scores_gemma":[0.0001694383,0.001711437,0.02051874,0.006667661,0.001500306,0.03956997,0.0004579803,0.001045171,0.07696603,0.008264892,0.8430343,0.00009395698],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005585257,0.9816827,0.002438596,0.001075575,0.0002179319,0.0000523216,0.00007613685,0.00003094196,0.008840638],"genre_scores_gemma":[0.02663507,0.9648383,0.002408243,0.000600414,0.0002937959,0.00003607049,0.0001292234,0.000007287089,0.005051472],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003995503,"threshold_uncertainty_score":0.01336628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3331959719031033,"score_gpt":0.5179051538150201,"score_spread":0.1847091819119168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}