{"id":"W2131572146","doi":"10.1126/science.1111915","title":"Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region","year":2005,"lang":"en","type":"article","venue":"Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Toronto; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Allosteric regulation; Phosphorylation; Transcription factor; Activator (genetics); Effector; DNA; Cell biology; DNA binding site; DNA-binding protein; Transcription (linguistics); Chemistry; Biology; Biochemistry; Biophysics; Promoter; Receptor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003587687,0.00005423491,0.00007142491,0.00005292468,0.00006842428,0.00002313371,0.0002703689,0.00004186302,0.000005741399],"category_scores_gemma":[0.0001883616,0.0000472293,0.00001374583,0.0002428253,0.0002026794,0.00001776174,0.0000396252,0.00004701207,0.000001287149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001852351,"about_ca_system_score_gemma":0.0001053637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004843924,"about_ca_topic_score_gemma":0.00005121826,"domain_scores_codex":[0.999225,0.00002134486,0.0001061875,0.0002307807,0.0001569215,0.000259829],"domain_scores_gemma":[0.9996292,0.000009899927,0.00003873603,0.0001833526,0.00005801271,0.00008077049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003118666,0.00001756082,0.0204465,0.000002714821,0.000001209258,4.604055e-7,0.00002210956,0.0001700874,0.9769154,0.00005452507,0.0000760458,0.002262216],"study_design_scores_gemma":[0.0005728484,0.0001081229,0.002189909,0.000008672755,8.331377e-7,0.000002725754,0.0000471844,0.006960776,0.988147,0.00002905242,0.001868712,0.00006420251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99788,0.0002459017,0.001536601,0.00008652472,0.00002908598,0.000088392,0.000006276578,0.000003380438,0.0001237845],"genre_scores_gemma":[0.998035,0.00002091569,0.001587687,0.00008469172,0.00002671906,0.000003692097,0.000007486849,0.000003784647,0.0002299903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01825659,"threshold_uncertainty_score":0.1925955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007835451580053556,"score_gpt":0.2616019470480898,"score_spread":0.2537664954680362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}