{"id":"W2131572146","doi":"10.1126/science.1111915","title":"Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region","year":2005,"lang":"en","type":"article","venue":"Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Toronto; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Allosteric regulation; Phosphorylation; Transcription factor; Activator (genetics); Effector; DNA; Cell biology; DNA binding site; DNA-binding protein; Transcription (linguistics); Chemistry; Biology; Biochemistry; Biophysics; Promoter; Receptor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174152,0.0002342405,0.0001618712,0.00008576463,0.0001641513,0.0002908411,0.0003230158,0.0001818665,0.0009088772],"category_scores_gemma":[0.0002178381,0.0001657528,0.0001245837,0.00006091427,0.0004719995,0.0003029465,0.0003369324,0.0004867646,0.0002254402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002268525,"about_ca_system_score_gemma":0.000137324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002319654,"about_ca_topic_score_gemma":0.0006376484,"domain_scores_codex":[0.9998873,0.00001428428,0.000006473941,0.00004138494,0.00003363972,0.00001697795],"domain_scores_gemma":[0.9998645,0.00003577936,0.00003470869,0.00001608208,0.00001038818,0.00003857439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009219936,0.000009411055,0.000134721,0.000008501579,0.000001868244,0.00004095093,0.00001102881,0.0002380236,0.9982011,0.0002984139,0.00000867474,0.0009549421],"study_design_scores_gemma":[0.00003464495,0.0001455736,0.001924504,0.000003051497,0.000006254163,0.0002103162,0.00002001076,0.003298617,0.9929605,0.0006159563,0.0007720313,0.00000839837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942912,0.0002794314,0.00447236,0.00006913707,0.00001542954,0.000009225391,0.00002649364,0.00003642483,0.0008002946],"genre_scores_gemma":[0.997803,0.0000708951,0.001511961,0.00002392845,0.000006851983,0.000004209742,0.00002441777,0.000009616823,0.0005451061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009088772,"threshold_uncertainty_score":0.003040493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007835451580053556,"score_gpt":0.2616019470480898,"score_spread":0.2537664954680362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}