{"id":"W2131589372","doi":"10.1074/jbc.m111.333278","title":"Mitochondrial 3β-Hydroxysteroid Dehydrogenase Enzyme Activity Requires Reversible pH-dependent Conformational Change at the Intermembrane Space","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; University of Alberta","keywords":"Chemistry; Circular dichroism; Conformational change; Dehydrogenase; Crystallography; Enzyme; Biophysics; Kinetics; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003761036,0.0001412407,0.0003158688,0.00002638263,0.0001013955,0.0000142766,0.0001201907,0.0001952654,0.0009874894],"category_scores_gemma":[0.000282724,0.00007383648,0.0002156031,0.00006563175,0.0001284188,0.0002009573,0.00009498568,0.0003351382,0.00004183291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764107,"about_ca_system_score_gemma":0.00005116336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003293439,"about_ca_topic_score_gemma":6.51731e-7,"domain_scores_codex":[0.9988722,0.0000501727,0.0003385221,0.00009992054,0.0003995259,0.000239646],"domain_scores_gemma":[0.9989436,0.0001244455,0.0003533116,0.0001545587,0.0001485681,0.000275565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001158388,0.0001602478,0.001241035,0.00003330959,0.00006125846,0.00004040644,0.0001076823,0.000001821162,0.9942785,0.000008438269,0.00203018,0.0008787335],"study_design_scores_gemma":[0.001588884,0.0002009882,0.008682332,0.00009180662,0.00007090971,0.003384395,0.0001071617,0.0001083987,0.9533592,0.00001463483,0.03227755,0.0001137683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936288,0.001225101,0.00004285971,0.003387928,0.0002384432,0.0001308227,0.00001102442,0.00001194832,0.00132306],"genre_scores_gemma":[0.996422,0.000170088,0.00007931382,0.000551746,0.001649357,0.000003883373,0.00001683415,0.000006494127,0.001100272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04091932,"threshold_uncertainty_score":0.9999257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06393851338245178,"score_gpt":0.2875998237078168,"score_spread":0.2236613103253651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}