{"id":"W2131592022","doi":"10.4161/mabs.28614","title":"A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy","year":2014,"lang":"en","type":"article","venue":"mAbs","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Council Canada","keywords":"Monoclonal antibody; Antibody; Canakinumab; Potency; In vivo; Immunology; Cytokine; Medicine; Immune system; Rheumatoid arthritis; Arthritis; Neutralization; Neutralizing antibody; Pharmacology; In vitro; Disease; Biology; Internal medicine; Anakinra; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004813654,0.0006794307,0.0004195039,0.0003563097,0.0001269188,0.0003193457,0.0005658686,0.00068105,0.00170663],"category_scores_gemma":[0.0002515655,0.0002041987,0.0003108676,0.000161352,0.0001631346,0.000285307,0.0001815134,0.0008751954,0.0005341417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000413536,"about_ca_system_score_gemma":0.0003558726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004971877,"about_ca_topic_score_gemma":0.0005034788,"domain_scores_codex":[0.9997608,0.00004451439,0.00001378818,0.00006041429,0.00005346344,0.00006696193],"domain_scores_gemma":[0.9998403,0.00003561458,0.00002913805,0.00002143053,0.00003600928,0.00003757024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001979669,0.0002467658,0.0001101553,0.00007160976,0.00001928788,0.00006968618,0.00001262697,0.0002430763,0.9908034,0.0002088612,0.000262761,0.007753857],"study_design_scores_gemma":[0.0003926643,0.00475429,0.002338491,0.00001671353,0.000116498,0.001296333,0.000007706948,0.002029465,0.9744017,0.0001441223,0.01448944,0.00001267681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9290307,0.01285706,0.04767086,0.0006753686,0.0004328086,0.0003511649,0.0009994055,0.000770439,0.007212267],"genre_scores_gemma":[0.9713548,0.003678795,0.01666456,0.0003950747,0.00013196,0.0001996846,0.002175557,0.00006645582,0.005333028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170663,"threshold_uncertainty_score":0.005709231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283484669469008,"score_gpt":0.2739818541241875,"score_spread":0.2611470074294974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}