{"id":"W2131592022","doi":"10.4161/mabs.28614","title":"A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy","year":2014,"lang":"en","type":"article","venue":"mAbs","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Council Canada","keywords":"Monoclonal antibody; Antibody; Canakinumab; Potency; In vivo; Immunology; Cytokine; Medicine; Immune system; Rheumatoid arthritis; Arthritis; Neutralization; Neutralizing antibody; Pharmacology; In vitro; Disease; Biology; Internal medicine; Anakinra; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736711,0.0001515404,0.0001558498,0.00006943251,0.00008467136,0.00003587292,0.0002016389,0.0001085587,0.00003779845],"category_scores_gemma":[0.00003829227,0.0001561775,0.00009383389,0.00007475544,0.00004343623,0.000006400662,0.000102833,0.0001060137,0.0000125442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001108458,"about_ca_system_score_gemma":0.00001696215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008630876,"about_ca_topic_score_gemma":0.00007475424,"domain_scores_codex":[0.9990738,0.00003194096,0.0002208356,0.0002916961,0.00007834044,0.000303386],"domain_scores_gemma":[0.9996079,0.000008724533,0.00004917415,0.0002718651,0.00002690698,0.00003540928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002139892,0.00007652648,0.009448671,0.00001223264,0.00001779575,0.000002251425,0.00009084686,0.0001013934,0.9891517,0.0003857808,0.0001761323,0.0005152255],"study_design_scores_gemma":[0.00246967,0.0002448446,0.07167305,0.00006892191,0.0000136147,0.00001612632,0.0001524713,0.0002314675,0.8854362,0.00005392075,0.03920316,0.0004365916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955285,0.0001299557,0.0006686783,0.0001086476,0.0001290014,0.0001016073,0.000002718803,0.00001484673,0.003316093],"genre_scores_gemma":[0.9989119,0.00001814866,0.0001683155,0.0002901304,0.0001381531,0.00000628174,0.00007782359,0.00002436157,0.0003648557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1037156,"threshold_uncertainty_score":0.6368732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283484669469008,"score_gpt":0.2739818541241875,"score_spread":0.2611470074294974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}