{"id":"W2131592861","doi":"10.1007/s40259-015-0130-9","title":"Next-Generation Covalent Irreversible Kinase Inhibitors in NSCLC: Focus on Afatinib","year":2015,"lang":"en","type":"review","venue":"BioDrugs","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"Boehringer Ingelheim","keywords":"Afatinib; Erlotinib; Gefitinib; Epidermal growth factor receptor; Lung cancer; Medicine; Oncology; Cetuximab; Internal medicine; EGFR inhibitors; Cancer research; Tyrosine kinase; Pharmacology; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004334257,0.0004586724,0.0006337822,0.0006099479,0.0001243317,0.0005062963,0.000455528,0.0007161631,0.001024873],"category_scores_gemma":[0.0003277521,0.0001734895,0.0004444498,0.000617607,0.0002409181,0.001184453,0.0003567997,0.001363789,0.0006651966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004492086,"about_ca_system_score_gemma":0.0003365645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003430118,"about_ca_topic_score_gemma":0.0009490711,"domain_scores_codex":[0.9998435,0.00003256673,0.00002115505,0.00003537216,0.00004313095,0.00002427544],"domain_scores_gemma":[0.9998949,0.00004392177,0.00001863985,0.0000032832,0.00002505085,0.00001430379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002094001,0.0001774478,0.0004720154,0.009799383,0.0001425626,0.0008242025,0.000136131,0.001401152,0.0191651,0.009133227,0.03273483,0.9258045],"study_design_scores_gemma":[0.00007010647,0.0008185208,0.0011748,0.0009190768,0.0001668851,0.00498335,0.00006183719,0.0007723478,0.00528434,0.00223862,0.9834803,0.00002996305],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001649482,0.9935921,0.001192647,0.000907453,0.0004466785,0.00001630594,0.00002747719,0.00002258672,0.002145197],"genre_scores_gemma":[0.013482,0.9805705,0.001283919,0.001247476,0.000728535,0.00002411784,0.00007872494,0.000008856733,0.002575847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001024873,"threshold_uncertainty_score":0.003428519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1326961338418439,"score_gpt":0.3950047831603708,"score_spread":0.2623086493185269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}