{"id":"W2131610677","doi":"10.1242/jcs.113.2.227","title":"Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase","year":2000,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":243,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; MAPK/ERK pathway; Cell biology; Protein kinase A; Cell culture; Matrigel; Matrix metalloproteinase; HaCaT; p38 mitogen-activated protein kinases; Collagenase; Molecular biology; Kinase; Gelatinase; Cancer research; Angiogenesis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054825,0.0003751983,0.0001772853,0.0001370103,0.0001355273,0.0003177086,0.0000978256,0.0002015186,0.0009101453],"category_scores_gemma":[0.00008484784,0.0001449482,0.0003056373,0.0001406611,0.0002082871,0.0002125095,0.0001268525,0.0004563885,0.0004310994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964795,"about_ca_system_score_gemma":0.0002011579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005657761,"about_ca_topic_score_gemma":0.000762089,"domain_scores_codex":[0.9998661,0.00001396409,0.00001331101,0.00002246798,0.00004671637,0.00003729996],"domain_scores_gemma":[0.9999135,0.00001128315,0.0000282264,0.0000119955,0.00001841237,0.0000166942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004815475,0.00001702801,0.0002435868,0.00002899311,0.000002486483,0.00004006586,0.0000124149,0.00001296063,0.9985732,0.00002441842,0.00001298726,0.0009835961],"study_design_scores_gemma":[0.000008140165,0.0002287218,0.01066774,0.000008900247,0.00001526514,0.0007293659,0.00005202072,0.000385877,0.9862936,0.00005493964,0.001551541,0.000003891807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888924,0.004713422,0.004206416,0.00008512272,0.00002767196,0.00005203066,0.0003776506,0.00008972506,0.001555474],"genre_scores_gemma":[0.9899181,0.003119426,0.003838455,0.00002595482,0.00001157213,0.00003533359,0.0004526028,0.000009513788,0.002589096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009101453,"threshold_uncertainty_score":0.003044724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007589504498583938,"score_gpt":0.2209703737188808,"score_spread":0.2133808692202968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}