{"id":"W2131617804","doi":"10.1038/ni.1932","title":"IFI16 is an innate immune sensor for intracellular DNA","year":2010,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1632,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NHLBI Division of Intramural Research; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Medical Research Council; Sundhed og Sygdom, Det Frie Forskningsråd; University of Toronto; Trinity College Dublin; National Institutes of Health; H. Lundbeck A/S; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Lundbeckfonden; Science Foundation Ireland; York University; University of Miami","keywords":"IRF3; AIM2; Innate immune system; Biology; DNA; Interferon; Stimulator of interferon genes; Cell biology; Pattern recognition receptor; TLR2; DNA virus; Interferon regulatory factors; Intracellular; Mediator; Transcription (linguistics); Gene; Genetics; Receptor; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000236508,0.0005393293,0.0002981889,0.0002781595,0.0002968566,0.0004591579,0.0002389442,0.0006807633,0.002491539],"category_scores_gemma":[0.0002315166,0.0001621327,0.0003456436,0.0001674356,0.0002863327,0.0005288404,0.0004670219,0.0009069817,0.001269468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003948972,"about_ca_system_score_gemma":0.0001718917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001382877,"about_ca_topic_score_gemma":0.0001408733,"domain_scores_codex":[0.9998246,0.00001952312,0.00001331428,0.00004252825,0.00006850041,0.00003153952],"domain_scores_gemma":[0.9998775,0.00001532758,0.00002755905,0.00001635564,0.0000297105,0.00003359271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001275191,0.00001401315,0.0004491447,0.00005894548,0.00000627592,0.00009585624,0.00002101541,0.00003839425,0.9909203,0.0003955118,0.0004546992,0.007418376],"study_design_scores_gemma":[0.00002152574,0.0002072191,0.004135565,0.00001536287,0.000009053608,0.001454121,0.00004469327,0.0006797641,0.9594722,0.000659632,0.03328829,0.00001258215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8929556,0.03332315,0.0437434,0.003618386,0.001542181,0.0001691895,0.0008957022,0.0009829412,0.02276936],"genre_scores_gemma":[0.9458219,0.006723753,0.02008392,0.000885681,0.000205691,0.00007817095,0.001282458,0.00007181433,0.02484661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002491539,"threshold_uncertainty_score":0.008334994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006877522458070944,"score_gpt":0.2559969805021183,"score_spread":0.2491194580440474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}