{"id":"W2131631796","doi":"10.1101/gad.198051.112","title":"Tyrosyl phosphorylation toggles a Runx1 switch","year":2012,"lang":"en","type":"letter","venue":"Genes & Development","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; Abramson Family Cancer Research Institute; National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Research Institute","keywords":"Phosphorylation; Biology; Transcription factor; RUNX1; Epigenetics; Acetylation; Methylation; Kinase; Cell biology; Transcription (linguistics); Phosphatase; Genetics; Gene; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000139055,0.0003116583,0.0001975124,0.00005937618,0.0001516552,0.00004433787,0.0002786996,0.0006428775,0.0001494279],"category_scores_gemma":[0.000006781606,0.0002981623,0.00009456598,0.00007482259,0.0000347619,0.000003520081,0.0001250647,0.0002446263,0.0002012365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008379554,"about_ca_system_score_gemma":0.0003692494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001402627,"about_ca_topic_score_gemma":0.0000121592,"domain_scores_codex":[0.9984805,0.00003359339,0.0003240059,0.0004758423,0.0002571314,0.0004289536],"domain_scores_gemma":[0.9991462,0.000005169626,0.0001631078,0.0005032187,0.0001195792,0.00006271827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001254517,0.00002697076,0.0007042967,0.00006718744,0.0001422474,0.000004381088,0.0001086719,0.000007383035,0.03621152,0.00001104414,0.8713171,0.09138659],"study_design_scores_gemma":[0.0001287294,0.00001620995,0.001972908,0.00002179098,0.00002603924,0.000008558279,0.00001353426,0.000001527616,0.08136942,0.00001437594,0.9160322,0.0003946919],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2412987,0.3312506,0.02372607,0.3652174,0.01123062,0.004073249,0.0002637361,0.0003439162,0.0225957],"genre_scores_gemma":[0.1541803,0.01207297,0.02928328,0.6485091,0.02533679,0.002370497,0.01912426,0.0005237249,0.1085991],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3191777,"threshold_uncertainty_score":0.9999471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711366822515624,"score_gpt":0.239028681360955,"score_spread":0.2219150131357987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}