{"id":"W2131631796","doi":"10.1101/gad.198051.112","title":"Tyrosyl phosphorylation toggles a Runx1 switch","year":2012,"lang":"en","type":"letter","venue":"Genes & Development","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; Abramson Family Cancer Research Institute; National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Research Institute","keywords":"Phosphorylation; Biology; Transcription factor; RUNX1; Epigenetics; Acetylation; Methylation; Kinase; Cell biology; Transcription (linguistics); Phosphatase; Genetics; Gene; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007085486,0.0004626756,0.0003498138,0.0001657914,0.0007550433,0.000903498,0.0003940328,0.006082245,0.003536738],"category_scores_gemma":[0.002435488,0.0002412763,0.0004084814,0.0001059601,0.001101169,0.0007301818,0.0005995259,0.006272444,0.003163309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001482887,"about_ca_system_score_gemma":0.0004379646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006643897,"about_ca_topic_score_gemma":0.001029323,"domain_scores_codex":[0.9995573,0.00009115438,0.00002957854,0.00006667541,0.0001732294,0.00008199283],"domain_scores_gemma":[0.9995246,0.0001975651,0.00005711293,0.00003857996,0.00007473466,0.0001075024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009159894,0.0001567518,0.001920682,0.0002083355,0.00006391767,0.009714869,0.0001954807,0.0003553134,0.05107502,0.01975536,0.8280419,0.08759637],"study_design_scores_gemma":[0.0003039086,0.0003239394,0.002507013,0.00007927575,0.00003532218,0.007081364,0.0001999091,0.001064286,0.02446644,0.01352047,0.9503688,0.00004915892],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02381811,0.01914303,0.002314862,0.8620523,0.06961014,0.00005214677,0.0001910884,0.0004574677,0.02236071],"genre_scores_gemma":[0.211068,0.01946004,0.001899025,0.6190156,0.07426348,0.000144889,0.0001697772,0.0001030468,0.07387607],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006082245,"threshold_uncertainty_score":0.01183152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711366822515624,"score_gpt":0.239028681360955,"score_spread":0.2219150131357987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}