{"id":"W2131650698","doi":"10.1039/b909153j","title":"Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics","year":2009,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Chemistry; Linker; DNA; Aminosugar; Doxorubicin; Anthracycline; Stereochemistry; Moiety; Daunorubicin; Biochemistry; Combinatorial chemistry; Cancer; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891477,0.0002681362,0.0002576333,0.0001358419,0.000114608,0.0001276652,0.000211607,0.0002861824,0.0009201562],"category_scores_gemma":[0.000280896,0.0001363017,0.0001430201,0.0001631172,0.0001045466,0.0001623345,0.0001096012,0.0003129346,0.0002541024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105831,"about_ca_system_score_gemma":0.00008468053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003265933,"about_ca_topic_score_gemma":0.0004298587,"domain_scores_codex":[0.9998705,0.00003465485,0.0000100052,0.0000274979,0.00003030443,0.00002704568],"domain_scores_gemma":[0.9998517,0.00003661564,0.00004498366,0.00001080512,0.00002890357,0.0000270929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000590528,0.0000330854,0.00004364017,0.00003375185,0.000003591131,0.00001212151,0.00001906793,0.0001507572,0.9985127,0.00005796074,0.00001190134,0.001062373],"study_design_scores_gemma":[0.00000626801,0.0002757103,0.0004485376,0.000002247225,0.00000648119,0.00004037546,0.000007269105,0.0003919677,0.9980901,0.000006998875,0.0007208263,0.000003256505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948495,0.001128851,0.002849276,0.00003169451,0.000009902787,0.00003508613,0.0001064595,0.00003084972,0.0009582791],"genre_scores_gemma":[0.9906508,0.0009252836,0.006367015,0.00004213213,0.000006423472,0.00002943236,0.0003097128,0.00001452847,0.001654787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009201562,"threshold_uncertainty_score":0.003078222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787023561749149,"score_gpt":0.2708432407384606,"score_spread":0.2429730051209691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}