{"id":"W2131690391","doi":"10.1158/0008-5472.can-15-0423","title":"WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; Ontario Institute for Cancer Research","funders":"Cancer Council NSW; Medical Research Council; Ministero dello Sviluppo Economico; University of New South Wales; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Neuroblastoma; Biology; Cancer research; Promoter; Histone; Molecular biology; Carcinogenesis; RNA interference; Mdm2; Gene expression; Regulation of gene expression; Gene; Cell culture; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006501297,0.0002325554,0.0003375389,0.0005837337,0.0001495642,0.00006904799,0.0002962153,0.0001282935,0.0008571067],"category_scores_gemma":[0.0001018241,0.0001861595,0.00008764766,0.0006738477,0.0002793246,0.0003336278,0.0001155776,0.001048478,0.00008443721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004619928,"about_ca_system_score_gemma":0.001281126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002348642,"about_ca_topic_score_gemma":0.0002637817,"domain_scores_codex":[0.9955767,0.0005224969,0.0002483461,0.0007098612,0.001937935,0.001004706],"domain_scores_gemma":[0.9978809,0.00007672171,0.00003844516,0.0005143175,0.000414767,0.001074831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002979132,0.0009018908,0.01616637,0.0001077716,0.00003246994,0.002567095,0.0007389233,0.00003348159,0.9687475,0.00004363191,0.005991101,0.001690627],"study_design_scores_gemma":[0.01136564,0.00505288,0.2040082,0.000468634,0.00002432025,0.0004298197,0.0006308011,0.000342542,0.7629622,0.0008879889,0.01341861,0.0004084028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951381,0.0005390981,0.00001769443,0.001460605,0.0001182876,0.001797204,0.00006596988,0.00007121349,0.0007918451],"genre_scores_gemma":[0.9965607,0.0001405217,0.000323993,0.000146202,0.0002667212,0.0008234709,0.0001359196,0.00006172046,0.001540733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2057853,"threshold_uncertainty_score":0.9384717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1975364755830004,"score_gpt":0.4374035864360187,"score_spread":0.2398671108530183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}