{"id":"W2131712791","doi":"10.1002/anie.201506500","title":"Controlled Transcription of Exogenous mRNA in Platelets Using Protocells","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Protocell; Messenger RNA; Platelet; Cell biology; Transcription (linguistics); Chemistry; Biology; Gene; Biochemistry; Membrane; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001915368,0.0003109394,0.0001632843,0.0001558914,0.0001373794,0.0003994198,0.0002028624,0.0003736764,0.0005856596],"category_scores_gemma":[0.000181348,0.0001481461,0.0002103892,0.0001440476,0.0002438912,0.0002299685,0.0002508314,0.0006157813,0.0004539382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004138223,"about_ca_system_score_gemma":0.0002488593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006749752,"about_ca_topic_score_gemma":0.0008751487,"domain_scores_codex":[0.9997949,0.00003215756,0.00001717073,0.00004614923,0.00008107108,0.00002865651],"domain_scores_gemma":[0.9999104,0.00003466675,0.000019131,0.00001289434,0.00001516417,0.00000787417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002270058,0.000003943408,0.00004918649,0.00003071555,0.000002515702,0.0000545296,0.0000266816,0.0001388476,0.9975311,0.0007086991,0.00006143026,0.001369576],"study_design_scores_gemma":[0.00000646984,0.00003075256,0.0000824778,0.000002295757,0.000004447606,0.00003042583,0.000005897208,0.0006756723,0.9969277,0.0000590178,0.002171975,0.000002912861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8478559,0.003448881,0.1348278,0.000607515,0.0003290996,0.0002475571,0.0009199819,0.0009606214,0.01080273],"genre_scores_gemma":[0.9613469,0.001666996,0.02953416,0.0001793095,0.00003063227,0.0001412381,0.0004543562,0.0001079758,0.006538485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006749752,"threshold_uncertainty_score":0.003002465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03825821024694953,"score_gpt":0.2835345227013676,"score_spread":0.2452763124544181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}