{"id":"W2131712791","doi":"10.1002/anie.201506500","title":"Controlled Transcription of Exogenous mRNA in Platelets Using Protocells","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Protocell; Messenger RNA; Platelet; Cell biology; Transcription (linguistics); Chemistry; Biology; Gene; Biochemistry; Membrane; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774482,0.00009778542,0.0001450392,0.00008031839,0.00001187459,0.00001241741,0.0001283033,0.000108847,0.00003787856],"category_scores_gemma":[0.0000646204,0.00009586091,0.00007879199,0.00005002248,0.00003447662,0.00001677804,0.00002099481,0.00005797147,0.000004995814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004747304,"about_ca_system_score_gemma":0.0000735816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007814504,"about_ca_topic_score_gemma":0.00002529012,"domain_scores_codex":[0.9992352,0.00001989734,0.0002692961,0.0001767903,0.0001889618,0.0001098276],"domain_scores_gemma":[0.9994881,0.000006124666,0.0001167651,0.00009786894,0.0002482548,0.0000429174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008378209,0.0001030944,0.0005798242,0.000008830738,0.00004326736,0.000005267174,0.0001185293,0.0002799061,0.9968911,0.00001284852,0.0009431412,0.0001763893],"study_design_scores_gemma":[0.003116935,0.0001660757,0.000162609,0.00004318799,0.0000104301,0.00001895016,0.0001097678,0.0003062178,0.9942529,0.0002073474,0.00150718,0.00009840056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934522,0.0001645401,0.002458249,0.00007926489,0.0005476592,0.0003864798,0.0000343164,0.00000568361,0.002871611],"genre_scores_gemma":[0.9984789,0.00006014879,0.0002223588,0.00009351731,0.0005360685,0.00007054586,0.0003148935,0.000009534479,0.000214014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005026723,"threshold_uncertainty_score":0.3909094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03825821024694953,"score_gpt":0.2835345227013676,"score_spread":0.2452763124544181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}