{"id":"W2131718574","doi":"10.1371/journal.pone.0000690","title":"The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist","year":2007,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":323,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"Industry Canada","keywords":"Citric acid cycle; Isocitrate dehydrogenase; Oxidative phosphorylation; NAD+ kinase; Biochemistry; Tricarboxylic acid; Dehydrogenase; Metabolic pathway; Biology; Oxidative stress; Reactive oxygen species; Metabolism; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003630178,0.0002702498,0.000512421,0.0003284643,0.0007631439,0.00226904,0.0003703114,0.000778964,0.001891632],"category_scores_gemma":[0.0003704115,0.0001725092,0.0002131733,0.0006286938,0.002296633,0.003703676,0.0009762881,0.001189246,0.0005217114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008945444,"about_ca_system_score_gemma":0.001000163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009337234,"about_ca_topic_score_gemma":0.001775826,"domain_scores_codex":[0.9998392,0.0000272219,0.00001161108,0.00006366793,0.0000298839,0.00002840235],"domain_scores_gemma":[0.9998265,0.00002856236,0.00002466389,0.00002818467,0.00004432921,0.00004780139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009108954,0.000038332,0.007096916,0.001196999,0.0001663248,0.001360204,0.001852904,0.002750729,0.1658021,0.5286384,0.01447437,0.275712],"study_design_scores_gemma":[0.00006261036,0.0003432732,0.019689,0.0005567729,0.0001261817,0.002602706,0.001927301,0.004787122,0.02368159,0.3191443,0.6269056,0.0001735232],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.340907,0.2947582,0.1675908,0.07966484,0.01042321,0.0000735143,0.00216879,0.001419729,0.1029939],"genre_scores_gemma":[0.8308664,0.09524825,0.03912251,0.00668778,0.002270817,0.00004930368,0.000512853,0.0001269496,0.02511511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00226904,"threshold_uncertainty_score":0.006490409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04557703108630586,"score_gpt":0.2792714092286699,"score_spread":0.2336943781423641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}