{"id":"W2131727392","doi":"10.1111/bjd.14164","title":"Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate‐to‐severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)","year":2015,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":479,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre de Recherche Dermatologique du Québec Métropolitain; SKiN Health","funders":"Celgene","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Adverse effect; Psoriasis Area and Severity Index; Internal medicine; Dermatology Life Quality Index; Nausea; Randomized controlled trial; Population; Tolerability; Dermatology; Psoriatic arthritis; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004995427,0.0001992741,0.001320464,0.0001332767,0.00005034331,0.00004165416,0.0001056472,0.0002100284,0.00001091895],"category_scores_gemma":[0.0003643393,0.0001691227,0.0001332778,0.00009597718,0.0001475732,0.00004277696,0.00004746084,0.0001655064,3.262753e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002700463,"about_ca_system_score_gemma":0.0002209458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004614231,"about_ca_topic_score_gemma":0.0001251629,"domain_scores_codex":[0.9976704,0.0005518323,0.001091245,0.0002355969,0.0002377206,0.0002132091],"domain_scores_gemma":[0.9985053,0.00008562837,0.0006056218,0.0001376614,0.0004186423,0.0002471702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9937942,0.0010552,0.001381421,0.00001023124,0.0002346073,0.00009258122,0.0002033418,0.0003099547,0.0005577902,0.000007287934,0.000713937,0.001639442],"study_design_scores_gemma":[0.9916552,0.001941684,0.001049469,0.0001277333,0.0001236433,0.001206903,0.00007500467,0.0001948913,0.003038389,0.00002837274,0.0003576296,0.0002010241],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959988,0.0006541855,0.001324765,0.00009633858,0.0004582827,0.001400079,0.0000192184,0.000004703027,0.00004364537],"genre_scores_gemma":[0.9990067,0.0001301982,0.0004314785,0.0001640652,0.000106789,0.00003195246,0.00007763426,0.00001928786,0.00003185462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003007958,"threshold_uncertainty_score":0.6896624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007377866692009705,"score_gpt":0.2451757533723236,"score_spread":0.2377978866803139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}