{"id":"W2131727392","doi":"10.1111/bjd.14164","title":"Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate‐to‐severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)","year":2015,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":479,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre de Recherche Dermatologique du Québec Métropolitain; SKiN Health","funders":"Celgene","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Adverse effect; Psoriasis Area and Severity Index; Internal medicine; Dermatology Life Quality Index; Nausea; Randomized controlled trial; Population; Tolerability; Dermatology; Psoriatic arthritis; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002836277,0.001361661,0.002416532,0.0003997015,0.0003946465,0.001029819,0.000690787,0.001591566,0.005494689],"category_scores_gemma":[0.001967933,0.0006258672,0.001913786,0.0003585465,0.0008618195,0.0008172779,0.0003057763,0.002294824,0.0007388245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004025347,"about_ca_system_score_gemma":0.0008928929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003285871,"about_ca_topic_score_gemma":0.0007409931,"domain_scores_codex":[0.999212,0.0004444272,0.00006172508,0.0001365069,0.00006966747,0.00007567144],"domain_scores_gemma":[0.9990528,0.0002834021,0.0002672094,0.00006758742,0.00006138447,0.0002676172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9705054,0.007096597,0.000690725,0.0006926644,0.0007142411,0.00003624729,0.00004333651,0.0002101482,0.003630962,0.00006722403,0.0006484925,0.01566404],"study_design_scores_gemma":[0.9582468,0.03948591,0.001392106,0.00002210575,0.0002169737,0.00002816952,0.000007477596,0.000156593,0.0001955276,0.00004028319,0.0002011255,0.000006944203],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859817,0.005736846,0.0005826849,0.0006727478,0.0003648001,0.003952466,0.0008370259,0.0001230325,0.00174862],"genre_scores_gemma":[0.9830766,0.003953832,0.001887868,0.001230893,0.0006078091,0.005740244,0.001149311,0.000025931,0.002327697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005494689,"threshold_uncertainty_score":0.01838154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007377866692009705,"score_gpt":0.2451757533723236,"score_spread":0.2377978866803139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}