{"id":"W2131747978","doi":"10.1093/carcin/bgn044","title":"Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers","year":2008,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital","funders":"","keywords":"CHEK2; Lung cancer; Cancer; Odds ratio; Medicine; Internal medicine; Cancer research; Prostate cancer; Oncology; Biology; Mutation; Germline mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007218965,0.0001104983,0.0001371759,0.00003460043,0.0001704076,0.00000431122,0.00006810154,0.00008860903,0.00001467774],"category_scores_gemma":[0.0001502873,0.0001059573,0.00004753257,0.00014601,0.0006832986,0.000003715509,0.00002629201,0.00004401892,5.540373e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050223,"about_ca_system_score_gemma":0.0006663048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001434702,"about_ca_topic_score_gemma":0.0003472446,"domain_scores_codex":[0.9993074,0.00005321749,0.000136605,0.0002368374,0.0001298552,0.0001360838],"domain_scores_gemma":[0.9993525,0.00003070617,0.0001440271,0.0001705734,0.0002288875,0.00007328147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007367577,0.00003302882,0.9762694,0.00001450093,0.0003133321,0.00001042752,0.0001265807,0.001644545,0.02049665,0.00005391502,0.0007210496,0.0002428422],"study_design_scores_gemma":[0.001208352,0.00009749346,0.8852004,0.00002758265,0.0002139686,0.00006413156,0.0001602208,0.0003062824,0.1118163,0.00001443324,0.0006851388,0.0002056096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955406,0.002397688,0.00101378,0.00003017321,0.00004402395,0.0001400408,0.0003993392,0.000009881341,0.0004244838],"genre_scores_gemma":[0.9986749,0.0002780762,0.0005888588,0.00006933498,0.00005114363,0.00005153154,0.0002089929,0.00001082404,0.00006637385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0913197,"threshold_uncertainty_score":0.4320814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240280857977741,"score_gpt":0.2329300996560141,"score_spread":0.2205272910762367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}