{"id":"W2131747978","doi":"10.1093/carcin/bgn044","title":"Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers","year":2008,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital","funders":"","keywords":"CHEK2; Lung cancer; Cancer; Odds ratio; Medicine; Internal medicine; Cancer research; Prostate cancer; Oncology; Biology; Mutation; Germline mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000310316,0.0003170125,0.000491717,0.001149134,0.0003167402,0.0004624361,0.000309096,0.000482867,0.003115082],"category_scores_gemma":[0.002481054,0.0002966475,0.0002381345,0.0009226767,0.0006705234,0.0002098943,0.0005253517,0.0003590805,0.0002567177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551706,"about_ca_system_score_gemma":0.0002176484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396368,"about_ca_topic_score_gemma":0.001756465,"domain_scores_codex":[0.9995389,0.00009108649,0.00005609685,0.0001663428,0.00008818307,0.00005935669],"domain_scores_gemma":[0.9983144,0.00026576,0.0009372996,0.0001488405,0.00008815336,0.0002455093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009288821,0.00004845702,0.9708301,0.00005569746,0.0001802042,0.0009018498,0.00006803597,0.0001826932,0.02024152,0.000152829,0.0001696456,0.006240108],"study_design_scores_gemma":[0.00002752145,0.0001091911,0.9950987,0.000007225483,0.00006933755,0.003029165,0.00004535037,0.0001867257,0.001107557,0.000113473,0.0002005989,0.000005206723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987842,0.0004953307,0.0001499324,0.00003425569,0.000004224387,0.000003009085,0.00008403637,0.00001435037,0.0004306293],"genre_scores_gemma":[0.9993969,0.0001791409,0.0001232746,0.00001058839,0.000008300106,0.000001656313,0.00008151037,0.000004768314,0.0001938248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003115082,"threshold_uncertainty_score":0.01042098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240280857977741,"score_gpt":0.2329300996560141,"score_spread":0.2205272910762367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}