{"id":"W2131755255","doi":"10.1096/fj.05-4869fje","title":"Impairment of the ubiquitin‐proteasome system in desminopathy mouse hearts","year":2005,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; American Heart Association","keywords":"Desmin; Proteasome; Ubiquitin; Cell biology; Proteolysis; Protein aggregation; Biology; Chemistry; Biochemistry; Immunology; Immunohistochemistry; Gene; Vimentin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003806819,0.001031652,0.0004610111,0.001862653,0.0003939299,0.0004804756,0.0004687463,0.0009624065,0.003053407],"category_scores_gemma":[0.0001822383,0.0006387375,0.0007000653,0.0003764447,0.0004895339,0.0004941092,0.0003567844,0.001039796,0.0009391758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005576079,"about_ca_system_score_gemma":0.0002327075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005726453,"about_ca_topic_score_gemma":0.0007764765,"domain_scores_codex":[0.9996529,0.00004180762,0.0000648006,0.0001124486,0.00006500498,0.00006312804],"domain_scores_gemma":[0.9996039,0.00005717835,0.0001399444,0.00003407597,0.00002695775,0.0001380461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002665557,0.00009258898,0.0003475393,0.00004028537,0.00001525036,0.0003413703,0.00004210696,0.00006265344,0.9978307,0.0001868349,0.00004631213,0.0007278782],"study_design_scores_gemma":[0.0001725932,0.001144668,0.02312812,0.00003292936,0.00008325645,0.002820416,0.00009974856,0.002181298,0.9671727,0.0003753158,0.002766673,0.00002231234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911277,0.00139597,0.00405445,0.0001961132,0.0000684613,0.00007817945,0.00128183,0.0003074339,0.001489831],"genre_scores_gemma":[0.9838847,0.001232478,0.005025353,0.0001530608,0.00003247014,0.000205966,0.001610192,0.0001336057,0.007722167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003053407,"threshold_uncertainty_score":0.01021463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083531965953326,"score_gpt":0.2232693465004244,"score_spread":0.2124340268408912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}