{"id":"W2131765662","doi":"10.1093/annonc/mdg171","title":"A phase II study of ZD0473 given as a short infusion every 3 weeks to patients with advanced or metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group trial, IND 129","year":2003,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; Jewish General Hospital; BC Cancer Agency","funders":"AstraZeneca Canada","keywords":"Medicine; Neutropenia; Internal medicine; Docetaxel; Metastatic breast cancer; Breast cancer; Carboplatin; Cancer; Clinical trial; Oncology; Phases of clinical research; Chemotherapy; Toxicity; Cisplatin; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001147961,0.001794484,0.002999906,0.0006233791,0.0006732037,0.001026926,0.001351678,0.001605442,0.006202341],"category_scores_gemma":[0.001096125,0.0007135961,0.001664252,0.0007479741,0.001466575,0.0007278617,0.0003279796,0.004332317,0.001315851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001354074,"about_ca_system_score_gemma":0.003263516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006435535,"about_ca_topic_score_gemma":0.01788959,"domain_scores_codex":[0.9996276,0.0001723001,0.00001178206,0.00005221088,0.00003395331,0.0001021598],"domain_scores_gemma":[0.9992829,0.0001374378,0.0001106076,0.0000539554,0.00003910378,0.0003760087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9035509,0.02394027,0.001642983,0.0005334186,0.0009157097,0.0001514644,0.0001431492,0.001562877,0.008325282,0.0003289536,0.006280597,0.05262446],"study_design_scores_gemma":[0.8939891,0.100569,0.002695797,0.00001538132,0.0002554964,0.00008253463,0.00003018054,0.000483592,0.0004899291,0.000094478,0.001277083,0.00001745982],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984198,0.003290919,0.0007036949,0.001665891,0.0003969666,0.002947151,0.002868026,0.000273742,0.003655663],"genre_scores_gemma":[0.9754983,0.004920691,0.002449652,0.001647094,0.0004031849,0.00296982,0.003500159,0.00007661506,0.008534562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006435535,"threshold_uncertainty_score":0.02074891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2271045426336996,"score_gpt":0.540438615129528,"score_spread":0.3133340724958283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}