{"id":"W2131769373","doi":"10.1530/rep-10-0268","title":"Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells","year":2010,"lang":"en","type":"article","venue":"Reproduction","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health; National Aeronautics and Space Administration","keywords":"Cellular differentiation; Cell biology; Trophoblast; Biology; Protein kinase A; Stem cell; AMPK; Kinase; Chemistry; Biochemistry; Placenta; Genetics; Fetus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004155224,0.0001859912,0.0002963825,0.0001365065,0.0001095089,0.00002075534,0.00006372568,0.0001327849,0.00002942245],"category_scores_gemma":[0.0000760537,0.000164492,0.00004311768,0.0002139935,0.0001233613,0.0001804537,0.00007551641,0.0004959243,0.00002276404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004940184,"about_ca_system_score_gemma":0.00005670534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001238176,"about_ca_topic_score_gemma":0.000143657,"domain_scores_codex":[0.99843,0.00007299062,0.0002754079,0.0006980149,0.0002635807,0.0002600301],"domain_scores_gemma":[0.9990706,0.00001477753,0.0001126558,0.0006316269,0.00008871661,0.00008157602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003207298,0.0002693204,0.05102624,0.0008326158,0.00005156276,0.0001128871,0.0008706489,0.00001098131,0.9404956,0.00009686781,0.0001382725,0.005774256],"study_design_scores_gemma":[0.001073417,0.0002031971,0.01853804,0.0005340838,0.000050623,0.00009510948,0.0003010824,0.00001185873,0.976071,0.000143004,0.002788136,0.0001904606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943687,0.001741205,0.00003174924,0.0009581492,0.000481778,0.001900098,0.000008372464,0.00009045186,0.0004194512],"genre_scores_gemma":[0.9947122,0.0002551425,0.0003903621,0.00001426649,0.0004475421,0.0001780045,0.000004667825,0.00002401432,0.003973739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03557536,"threshold_uncertainty_score":0.670779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321558391921819,"score_gpt":0.2296699717455556,"score_spread":0.2164543878263374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}