{"id":"W2131786456","doi":"10.1371/journal.pgen.1004256","title":"DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; University Health Network; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université Laval; Centre hospitalier universitaire de Québec","funders":"National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; Cancer Center, University of Kansas; National Institutes of Health; Ministero dello Sviluppo Economico; Fox Chase Cancer Center; Uppsala Universitet; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Cancer Research UK; KWF Kankerbestrijding; NIH Office of the Director; Deutsche Krebshilfe; National Cancer Institute; Landspítali Háskólasjúkrahús; Hungarian Scientific Research Fund; Lunds Universitet; Sahlgrenska Universitetssjukhuset; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Breast Cancer Foundation; European Commission; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; University of Chicago; Instituto de Salud Carlos III; Hope Funds for Cancer Research; Royal Marsden NHS Foundation Trust; McGill University; European Social Fund; Canadian Breast Cancer Research Alliance; State Education Development Agency Republic of Latvia; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of California, San Francisco; Ministero della Salute; National Health and Medical Research Council; Kansas Bioscience Authority","keywords":"DNA glycosylase; Biology; MUTYH; DNA repair; Base excision repair; Genetics; Single-nucleotide polymorphism; Cancer; Mutation; Breast cancer; Cancer research; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006951208,0.000494789,0.0005234758,0.00125173,0.000377578,0.0004543586,0.0002979306,0.0006812169,0.001748284],"category_scores_gemma":[0.00239372,0.0002869662,0.0006048085,0.0009963361,0.0003805134,0.0002016922,0.0003377762,0.0004615322,0.0001711505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001385637,"about_ca_system_score_gemma":0.0001624998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002770527,"about_ca_topic_score_gemma":0.002356882,"domain_scores_codex":[0.9995738,0.0001106005,0.00003923273,0.0001653044,0.00005823781,0.00005289744],"domain_scores_gemma":[0.9988344,0.0004597061,0.0003580365,0.0001177422,0.00006312348,0.0001669967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006737647,0.00005017037,0.9839647,0.0000193565,0.0002745149,0.0007244313,0.0002218084,0.000104366,0.01133765,0.00004285316,0.00005405798,0.002532324],"study_design_scores_gemma":[0.00001867798,0.0001198362,0.9978568,0.000004376923,0.0001529726,0.0009170025,0.00006577458,0.0001380803,0.0005398644,0.00005716137,0.0001245165,0.000004941555],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995453,0.0001953527,0.00007391962,0.00001274063,0.000001921788,0.000002938964,0.00007721852,0.000002911222,0.0000876656],"genre_scores_gemma":[0.9994099,0.00009010275,0.0001448314,0.00001583396,0.000006469048,0.00000581267,0.0001523323,0.000003690743,0.0001710595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002770527,"threshold_uncertainty_score":0.005848646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502615622196476,"score_gpt":0.2554537028438997,"score_spread":0.2404275466219349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}