{"id":"W2131786456","doi":"10.1371/journal.pgen.1004256","title":"DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; University Health Network; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université Laval; Centre hospitalier universitaire de Québec","funders":"National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; Cancer Center, University of Kansas; National Institutes of Health; Ministero dello Sviluppo Economico; Fox Chase Cancer Center; Uppsala Universitet; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Cancer Research UK; KWF Kankerbestrijding; NIH Office of the Director; Deutsche Krebshilfe; National Cancer Institute; Landspítali Háskólasjúkrahús; Hungarian Scientific Research Fund; Lunds Universitet; Sahlgrenska Universitetssjukhuset; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Breast Cancer Foundation; European Commission; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; University of Chicago; Instituto de Salud Carlos III; Hope Funds for Cancer Research; Royal Marsden NHS Foundation Trust; McGill University; European Social Fund; Canadian Breast Cancer Research Alliance; State Education Development Agency Republic of Latvia; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of California, San Francisco; Ministero della Salute; National Health and Medical Research Council; Kansas Bioscience Authority","keywords":"DNA glycosylase; Biology; MUTYH; DNA repair; Base excision repair; Genetics; Single-nucleotide polymorphism; Cancer; Mutation; Breast cancer; Cancer research; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002902735,0.0001935057,0.0001919634,0.0001181582,0.00006304717,0.00002362045,0.000113415,0.0002020674,0.00001634243],"category_scores_gemma":[0.0004623834,0.0001925737,0.0000365853,0.0002624736,0.0001179456,0.000006383192,0.00006925603,0.0001435263,9.69916e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001791426,"about_ca_system_score_gemma":0.0002382817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001793512,"about_ca_topic_score_gemma":0.01530844,"domain_scores_codex":[0.9985278,0.0002130993,0.0002844987,0.0004947154,0.0002096218,0.0002703051],"domain_scores_gemma":[0.9992345,0.00007032986,0.0001487582,0.0003358742,0.0001241872,0.0000863821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003077042,0.0002372128,0.8154423,0.00006310103,0.000206807,0.00001926736,0.001102045,0.01574047,0.1613744,0.00001068131,0.0009926365,0.004503483],"study_design_scores_gemma":[0.004946182,0.0009229659,0.2197915,0.0002334213,0.0001732773,0.000006131624,0.0007804584,0.04150884,0.7275558,0.0002518779,0.003036881,0.0007927755],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975905,0.001544792,0.0001261051,0.0001563732,0.00008014579,0.000300927,0.00009196775,0.00002265724,0.00008653884],"genre_scores_gemma":[0.9973021,0.0008833195,0.001076266,0.0002891136,0.00008221916,0.0001055879,0.000163661,0.00004279459,0.00005490114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5956508,"threshold_uncertainty_score":0.8542472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502615622196476,"score_gpt":0.2554537028438997,"score_spread":0.2404275466219349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}