{"id":"W2131810775","doi":"10.1084/jem.20072248","title":"C5 deficiency and C5a or C5aR blockade protects against cerebral malaria","year":2008,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Toronto General Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Congenic; Plasmodium berghei; Complement component 5; Biology; Allele; Blockade; Cerebral Malaria; Immunology; Phenotype; C57BL/6; Pathogenesis; Parasitemia; Malaria; Complement system; Receptor; Plasmodium falciparum; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003376541,0.0009720048,0.0005851156,0.0006535308,0.0002858042,0.0003601816,0.000485668,0.0006069503,0.001543305],"category_scores_gemma":[0.0002080792,0.000346159,0.0003943212,0.0002247858,0.0004502426,0.0002990675,0.0002588,0.001619562,0.000332288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003142204,"about_ca_system_score_gemma":0.0004530663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001224775,"about_ca_topic_score_gemma":0.002112325,"domain_scores_codex":[0.9996414,0.00006406861,0.00003911912,0.00005652607,0.00006162606,0.0001372368],"domain_scores_gemma":[0.9995944,0.00004225353,0.0001121709,0.00004607225,0.00002781255,0.0001774186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001464591,0.0004669793,0.0002661942,0.00007419617,0.00003175482,0.00009544237,0.00003169464,0.0001053732,0.994958,0.000180543,0.0001471621,0.002178131],"study_design_scores_gemma":[0.0003275407,0.008463701,0.01148399,0.00004796281,0.0001130632,0.0005870329,0.00007598165,0.001367288,0.9746187,0.0001398466,0.002751434,0.00002360444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952442,0.001560189,0.001009378,0.0002022151,0.00007273768,0.00006355423,0.0004127161,0.0001174417,0.001317608],"genre_scores_gemma":[0.9940055,0.001294919,0.001383215,0.0001710103,0.00004518014,0.0001033961,0.0005490295,0.00002768183,0.002420153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001543305,"threshold_uncertainty_score":0.005162895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03448588868187857,"score_gpt":0.3090488896778265,"score_spread":0.2745630009959479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}