{"id":"W2131810775","doi":"10.1084/jem.20072248","title":"C5 deficiency and C5a or C5aR blockade protects against cerebral malaria","year":2008,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Toronto General Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Congenic; Plasmodium berghei; Complement component 5; Biology; Allele; Blockade; Cerebral Malaria; Immunology; Phenotype; C57BL/6; Pathogenesis; Parasitemia; Malaria; Complement system; Receptor; Plasmodium falciparum; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007733309,0.0001854678,0.0004780614,0.0001605456,0.0002202319,0.000007441404,0.000213677,0.00006615585,0.0006594398],"category_scores_gemma":[0.0004512132,0.00008545989,0.00006952527,0.0002027588,0.0005371682,0.0001057376,0.00007077292,0.0005301834,0.000009534363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007892264,"about_ca_system_score_gemma":0.0002273902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004609736,"about_ca_topic_score_gemma":0.000002121899,"domain_scores_codex":[0.9980461,0.0001478755,0.0004973894,0.000129189,0.0008246663,0.0003547595],"domain_scores_gemma":[0.9988386,0.0001457074,0.0002245859,0.0002385678,0.0001419857,0.0004105679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009481791,0.0005549088,0.001199915,0.00006548039,0.0001795597,0.001715298,0.005267716,0.000002649953,0.9739956,0.000437378,0.005220713,0.001878944],"study_design_scores_gemma":[0.07861999,0.05648551,0.082609,0.002545318,0.0006463086,0.08517794,0.02709179,0.001348132,0.6554661,0.0003500179,0.008822978,0.0008368561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651575,0.01158121,0.0001073404,0.01861781,0.0001934714,0.0006805342,0.00000130072,0.00001561872,0.003645188],"genre_scores_gemma":[0.9961528,0.0005987922,0.0002905903,0.001119947,0.000840777,0.000009990806,0.000001151305,0.00002012387,0.0009658983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3185295,"threshold_uncertainty_score":0.7220404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03448588868187857,"score_gpt":0.3090488896778265,"score_spread":0.2745630009959479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}