{"id":"W2131813709","doi":"10.1530/jme-11-0016","title":"Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression","year":2011,"lang":"en","type":"article","venue":"Journal of Molecular Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal; University Health Network; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; San Diego State University; Canadian Institutes of Health Research; College of Engineering, Michigan State University; National Institutes of Health; Michigan State University","keywords":"Transcription factor; Promoter; Biology; Chromatin immunoprecipitation; Molecular biology; ATF6; Reporter gene; Insulin; Endoplasmic reticulum; Gene; Gene expression; Chemistry; Cell biology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002315691,0.0003643552,0.0002633468,0.000173951,0.0001784996,0.0002886323,0.0002858372,0.0002279987,0.001941129],"category_scores_gemma":[0.0003260392,0.0001593902,0.000547863,0.0001648368,0.0002374174,0.0001804327,0.0002961595,0.0005463056,0.0007845867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003009536,"about_ca_system_score_gemma":0.0003549897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112516,"about_ca_topic_score_gemma":0.001090836,"domain_scores_codex":[0.9995918,0.0000628592,0.00003509067,0.0001152722,0.0001192131,0.00007587077],"domain_scores_gemma":[0.9996961,0.00006371117,0.00007350068,0.00004272522,0.00004631671,0.00007761953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009122055,0.00002537676,0.0002168765,0.00003399602,0.000004642916,0.00001798912,0.00001091002,0.00002738005,0.998713,0.00006724751,0.00002157809,0.0007698001],"study_design_scores_gemma":[0.00001536449,0.0002749406,0.007048497,0.00002035084,0.00001354968,0.0002181386,0.00004491908,0.001423073,0.9877005,0.00007832503,0.003156701,0.00000578289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810491,0.002574191,0.01296354,0.0001039266,0.00006462729,0.00003344517,0.0004828188,0.0000991945,0.002629111],"genre_scores_gemma":[0.9875367,0.000617274,0.006639381,0.0001170291,0.00001623545,0.00002850046,0.002066001,0.00003379114,0.002944976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941129,"threshold_uncertainty_score":0.006493688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05143671180950702,"score_gpt":0.2705530039602837,"score_spread":0.2191162921507767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}