{"id":"W2131831977","doi":"10.4049/jimmunol.192.supp.63.16","title":"Peroxisome proliferator-activated receptor-alpha (PPARα) suppresses T helper 1 (Th1) cytokine production in male mice by inducing post-translational histone modifications at the interferon-gamma (IFNγ) locus (IRM6P.724)","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; University Health Network","funders":"","keywords":"Chromatin immunoprecipitation; Biology; Histone; Peroxisome proliferator-activated receptor; Molecular biology; Cytokine; Repressor; Nuclear receptor; Psychological repression; Promoter; Receptor; Transcription factor; Gene expression; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002432463,0.0006625108,0.0004052868,0.0007211404,0.0002645782,0.0003861087,0.0002649793,0.0004128577,0.00365463],"category_scores_gemma":[0.00008184226,0.0003924151,0.0005097949,0.0002498611,0.0005162737,0.0001961636,0.0002707945,0.001312101,0.001073634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002655651,"about_ca_system_score_gemma":0.0001785813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000285851,"about_ca_topic_score_gemma":0.0005205044,"domain_scores_codex":[0.9996196,0.00006038923,0.00003345458,0.00009706086,0.00009383134,0.00009559808],"domain_scores_gemma":[0.9997746,0.00001501256,0.000101959,0.00002332821,0.00001165057,0.00007349117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002158809,0.00003204165,0.0001558324,0.00001681047,0.000003759737,0.00002342792,0.000007771864,0.00001521216,0.9991181,0.00003362522,0.00001618599,0.0003610897],"study_design_scores_gemma":[0.00004902222,0.0007844853,0.006700543,0.000009742507,0.00002763729,0.0002772331,0.00005387565,0.0003125612,0.9902923,0.00005681066,0.001430423,0.000005449131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945692,0.0009562675,0.002135591,0.0001659473,0.00007983344,0.00002525385,0.0008041774,0.0001357629,0.001128143],"genre_scores_gemma":[0.9879636,0.0007890143,0.001882474,0.0001443958,0.00004410615,0.00005968905,0.0008332973,0.0001025325,0.008180995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00365463,"threshold_uncertainty_score":0.01222593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091781448179481,"score_gpt":0.2336025172429238,"score_spread":0.222684702761129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}