{"id":"W2131847309","doi":"10.1128/mcb.02300-07","title":"Phosphorylation of p27 <sup>Kip1</sup> Regulates Assembly and Activation of Cyclin D1-Cdk4","year":2008,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institutes of Health; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; National Cancer Institute; Doris Duke Charitable Foundation","keywords":"Cyclin D1; Cyclin D; Cyclin A2; Cyclin-dependent kinase complex; Cyclin A; Cell biology; Cancer research; Phosphorylation; Cyclin E; Cyclin-dependent kinase; Cyclin B; Biology; Cyclin-dependent kinase 2; Cell cycle; Biochemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006389582,0.0003201862,0.0001432786,0.0002359355,0.0001970884,0.0003267823,0.000156966,0.0001199987,0.002656413],"category_scores_gemma":[0.00009061271,0.000145136,0.0001784609,0.0001209055,0.0001679717,0.0001593811,0.0001742606,0.0003297073,0.0009734659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005910807,"about_ca_system_score_gemma":0.0002118102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009802978,"about_ca_topic_score_gemma":0.001200337,"domain_scores_codex":[0.9999266,0.00000722598,0.000004072144,0.00001658458,0.00001531686,0.00003033504],"domain_scores_gemma":[0.9999484,0.000007369271,0.00001308422,0.000004731678,0.000007007487,0.00001939339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001552577,0.00002053922,0.0006747327,0.00003931988,0.000002859285,0.00008559338,0.0000126864,0.0000679732,0.9963089,0.0001577021,0.0001228184,0.002351615],"study_design_scores_gemma":[0.000006908386,0.00007767274,0.01460361,0.000005043243,0.000004120931,0.0001540764,0.00002181268,0.0007049828,0.9805142,0.00005748987,0.003847033,0.000003028017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906364,0.003339752,0.001832297,0.0001062295,0.00002573457,0.00002161211,0.0005076153,0.0001132655,0.00341711],"genre_scores_gemma":[0.9896702,0.001964669,0.001200552,0.00003243696,0.00001231177,0.00003427522,0.001028517,0.00003235694,0.006024681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002656413,"threshold_uncertainty_score":0.008886516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026953985840499,"score_gpt":0.2274641197850054,"score_spread":0.2171945799266004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}