{"id":"W2131856428","doi":"10.1038/emboj.2011.257","title":"Regulation of TFEB and V‐ATPases by mTORC1","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":460,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Massachusetts General Hospital; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Biomedical Imaging and Bioengineering; U.S. Public Health Service; Generalitat Valenciana; York University; University of Texas Southwestern Medical Center; Johns Hopkins University; Brigham and Women's Hospital; National Cancer Institute; March of Dimes Foundation","keywords":"Biology; TFEB; mTORC1; ATPase; Cell biology; Lysosome; Biochemistry; Enzyme; Signal transduction; PI3K/AKT/mTOR pathway","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002693772,0.0004937354,0.0003734881,0.0004310937,0.0005057262,0.001378789,0.0003176396,0.0005115365,0.001719817],"category_scores_gemma":[0.0003582091,0.0002749054,0.0002701634,0.0001956085,0.0004380966,0.0007815705,0.0004441441,0.0004791344,0.0007206282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001029463,"about_ca_system_score_gemma":0.0004009922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001116927,"about_ca_topic_score_gemma":0.001650494,"domain_scores_codex":[0.999763,0.00003058761,0.00002039655,0.0000534211,0.00004935369,0.0000832775],"domain_scores_gemma":[0.9998298,0.00002253154,0.00004489953,0.00001416435,0.00003916038,0.00004936151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001615974,0.0000619579,0.001037033,0.0002209926,0.00004246681,0.0003250528,0.00004743907,0.0003321539,0.9803104,0.003733837,0.001216215,0.01105652],"study_design_scores_gemma":[0.00006738269,0.0001609865,0.01510086,0.00002759779,0.00003051038,0.0008397416,0.0001648959,0.003230517,0.9631291,0.001036293,0.01618719,0.00002487163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9283635,0.05156327,0.005009145,0.001679923,0.0003891291,0.00003798487,0.001023697,0.0003457396,0.01158763],"genre_scores_gemma":[0.9886323,0.004225525,0.001292303,0.000130953,0.00006196905,0.00002047623,0.0007108928,0.0000508876,0.004874683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001719817,"threshold_uncertainty_score":0.007469296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007011683475463,"score_gpt":0.2242189926358538,"score_spread":0.2041488758010992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}