{"id":"W2131922759","doi":"10.1371/journal.pone.0005105","title":"HD-PTP Is a Catalytically Inactive Tyrosine Phosphatase Due to a Conserved Divergence in Its Phosphatase Domain","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Kidney Foundation of Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; McGill University","keywords":"Protein tyrosine phosphatase; Phosphatase; Protein phosphatase 2; Tyrosine; Biology; Biochemistry; DUSP6; Phosphorylation; Tyrosine phosphorylation; Amino acid; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490359,0.0002823556,0.0002109199,0.0002205271,0.0001426424,0.000267641,0.000204496,0.0002378141,0.001044883],"category_scores_gemma":[0.000203157,0.00007558593,0.0002084706,0.0002285185,0.0004305957,0.0001674016,0.0002534068,0.0003977845,0.0002648848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000303516,"about_ca_system_score_gemma":0.0001393137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002657968,"about_ca_topic_score_gemma":0.0001610258,"domain_scores_codex":[0.9998988,0.00001286046,0.00001103013,0.00003506862,0.00002876151,0.00001346753],"domain_scores_gemma":[0.9998466,0.00003178825,0.00005967281,0.00001834426,0.00001512615,0.00002842288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001816861,0.00002627692,0.004202262,0.00008022827,0.00002666683,0.000891887,0.00002122967,0.0001576212,0.9884194,0.0007943387,0.00007563036,0.005122839],"study_design_scores_gemma":[0.00004201251,0.000435289,0.04872531,0.00001589511,0.0001029142,0.01661081,0.00007064165,0.00204852,0.9185957,0.0007197673,0.01262055,0.00001253217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849042,0.002304426,0.01067099,0.00008687571,0.00004130866,0.00002181832,0.0005619528,0.00007109954,0.001337323],"genre_scores_gemma":[0.995495,0.0004844668,0.002399383,0.00002954186,0.00001358044,0.000009060534,0.0007550382,0.000008686483,0.0008053049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044883,"threshold_uncertainty_score":0.003495455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262623903783277,"score_gpt":0.2451344565579212,"score_spread":0.2225082175200884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}