{"id":"W2131922759","doi":"10.1371/journal.pone.0005105","title":"HD-PTP Is a Catalytically Inactive Tyrosine Phosphatase Due to a Conserved Divergence in Its Phosphatase Domain","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Kidney Foundation of Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; McGill University","keywords":"Protein tyrosine phosphatase; Phosphatase; Protein phosphatase 2; Tyrosine; Biology; Biochemistry; DUSP6; Phosphorylation; Tyrosine phosphorylation; Amino acid; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002881273,0.0003869945,0.000484976,0.0001016775,0.0001444218,0.00004771214,0.0005912915,0.0001940502,0.0001769775],"category_scores_gemma":[0.000739948,0.0004150868,0.00008826935,0.0004795751,0.00009388999,0.00002551904,0.0006103492,0.000204139,0.0002473135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008868858,"about_ca_system_score_gemma":0.0001494178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002550798,"about_ca_topic_score_gemma":0.0001424311,"domain_scores_codex":[0.9974805,0.00007467582,0.0004675632,0.0008639828,0.0004551215,0.0006582006],"domain_scores_gemma":[0.9984117,0.0000343228,0.0001317877,0.0008220798,0.0002124066,0.0003877363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002966161,0.006181872,0.004554837,0.0001811972,0.0003149465,0.0006625434,0.0003850661,0.0000143983,0.9619011,0.006663773,0.01412854,0.002045559],"study_design_scores_gemma":[0.001507847,0.0009652347,0.007452573,0.0002390152,0.00006277059,0.00001238358,0.00002823124,0.0000350872,0.9878072,0.0007148713,0.0006614309,0.000513421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634302,0.02891199,0.0003216912,0.002856719,0.00006149512,0.001567314,0.002609539,0.00005526965,0.0001857438],"genre_scores_gemma":[0.9866351,0.0003889272,0.005340282,0.006045885,0.0001148726,0.0001695198,0.001006718,0.00003849862,0.0002602191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02852307,"threshold_uncertainty_score":0.9998301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262623903783277,"score_gpt":0.2451344565579212,"score_spread":0.2225082175200884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}