{"id":"W2131974830","doi":"10.1091/mbc.e05-09-0858","title":"DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Cancer Research Society","keywords":"Biology; DNA damage; Phosphorylation; Interferon; Senescence; Cell biology; Reactive oxygen species; Serine; Signal transduction; Dephosphorylation; Cell cycle; Molecular biology; Cell; DNA; Biochemistry; Immunology; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001520538,0.0001389144,0.0002167211,0.00005966059,0.00004538311,0.000006532102,0.0001103775,0.0001231162,0.00002646778],"category_scores_gemma":[0.0000234646,0.00009823392,0.00007353569,0.00008507435,0.0001956894,0.00002119776,0.00008301436,0.0001359,0.00000533507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000202597,"about_ca_system_score_gemma":0.00002686198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007683015,"about_ca_topic_score_gemma":0.00001506196,"domain_scores_codex":[0.999084,0.0001178826,0.0002269586,0.0002639823,0.0001108424,0.0001963337],"domain_scores_gemma":[0.9994597,0.00003000945,0.0001030516,0.0003066074,0.0000584962,0.00004216527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000217674,0.00007281475,0.06375746,0.00006562043,0.00001227463,0.00002644427,0.00007008561,0.00005185456,0.9353376,0.00002960171,0.00001373565,0.0003447982],"study_design_scores_gemma":[0.0007207962,0.0002031087,0.07147211,0.00006170632,0.00006667954,0.0000189411,0.00002089837,0.0003283673,0.9266606,0.0002581378,0.00008604824,0.0001026204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954646,0.001018165,0.002443281,0.0003688909,0.0001041544,0.0003200004,0.000006165248,0.00002260767,0.0002521873],"genre_scores_gemma":[0.9986906,0.00001117597,0.0006455093,0.0002436623,0.00004201188,0.000008664445,0.00001471147,0.00001437721,0.0003292704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008677041,"threshold_uncertainty_score":0.4005863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005149563283334937,"score_gpt":0.2275303058664417,"score_spread":0.2223807425831067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}