{"id":"W2132011506","doi":"10.1021/jm901018f","title":"Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Carbazole; DU145; Kinase; In vitro; Lead compound; Structure–activity relationship; Biochemistry; Stereochemistry; Cancer cell; Cancer; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001336647,0.0001586745,0.0005226856,0.000128147,0.00002509358,0.000007422446,0.00006856487,0.0001254802,0.0001124888],"category_scores_gemma":[0.0005453251,0.0001255458,0.000098095,0.0001801768,0.00007305094,0.0001003216,0.00001012188,0.0004025646,2.650633e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294116,"about_ca_system_score_gemma":0.0009557296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002675893,"about_ca_topic_score_gemma":0.000001830959,"domain_scores_codex":[0.998021,0.00004738326,0.0006241981,0.0001504517,0.0009904207,0.0001665455],"domain_scores_gemma":[0.9986966,0.00006195799,0.0004445349,0.000135272,0.0003989275,0.0002627401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001871594,0.0001770766,0.0002436624,0.00009095428,0.00003666754,0.0001485276,0.0005106432,0.000007279833,0.9186902,0.000002986257,0.0006135317,0.07760688],"study_design_scores_gemma":[0.004500764,0.0004595906,0.003425965,0.001236128,0.0002559631,0.0005505488,0.001095249,0.0001430266,0.9873703,0.0005676381,0.0002931599,0.0001016502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870831,0.009630569,0.00005129004,0.002569783,0.0001334888,0.0001446101,0.000002888547,0.000004577288,0.000379647],"genre_scores_gemma":[0.9976816,0.0004485848,0.0004774251,0.0002960875,0.001032777,0.000001796463,0.000002274238,0.00000994879,0.0000495145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07750523,"threshold_uncertainty_score":0.5119609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02125981076005875,"score_gpt":0.2935554209193602,"score_spread":0.2722956101593015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}