{"id":"W2132011506","doi":"10.1021/jm901018f","title":"Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Carbazole; DU145; Kinase; In vitro; Lead compound; Structure–activity relationship; Biochemistry; Stereochemistry; Cancer cell; Cancer; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002358015,0.00036121,0.0003609221,0.0003397282,0.0002032905,0.000239476,0.0003357372,0.0001545067,0.001282804],"category_scores_gemma":[0.0002262516,0.0001762919,0.0001977572,0.0002616978,0.0001274586,0.0001891564,0.0001308027,0.0004368197,0.0003690522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768396,"about_ca_system_score_gemma":0.0002325974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004629646,"about_ca_topic_score_gemma":0.001065859,"domain_scores_codex":[0.9999002,0.00002302146,0.0000121336,0.00001233913,0.00003241059,0.00001983825],"domain_scores_gemma":[0.9999243,0.00002176806,0.00001022719,0.000007727223,0.00001499483,0.00002092162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002971443,0.0002801659,0.0001882249,0.0002635517,0.00001449229,0.0002685732,0.00005571703,0.001281247,0.9865091,0.0002350363,0.000222499,0.01038418],"study_design_scores_gemma":[0.0001109874,0.001616242,0.001632758,0.00001591179,0.00005205959,0.0003166746,0.00001921638,0.001242286,0.9880174,0.00005885649,0.006905907,0.00001174763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691611,0.01355962,0.006901344,0.0002192331,0.00009565772,0.0003551598,0.001897276,0.0001252918,0.007685211],"genre_scores_gemma":[0.9692193,0.01280654,0.01156729,0.00009615794,0.00006953409,0.0002079783,0.002298202,0.00002212658,0.003712808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001282804,"threshold_uncertainty_score":0.004291415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02125981076005875,"score_gpt":0.2935554209193602,"score_spread":0.2722956101593015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}