{"id":"W2132046208","doi":"10.2337/db11-1711","title":"Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice","year":2012,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":599,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"PDX1; Progenitor cell; Embryonic stem cell; Pancreas; Biology; Stem cell; Endocrinology; Internal medicine; Insulin; Population; Diabetes mellitus; Pancreatic islets; Islet; Streptozotocin; Enteroendocrine cell; Endocrine system; Medicine; Cell biology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003270005,0.0002997069,0.0001791461,0.0002312777,0.0001036669,0.0003389873,0.0002219988,0.0001722921,0.001458044],"category_scores_gemma":[0.0001457552,0.0002120442,0.0002601713,0.000122891,0.000160723,0.000184801,0.0001773464,0.0007508114,0.000562862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187678,"about_ca_system_score_gemma":0.0001914108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001318603,"about_ca_topic_score_gemma":0.0002129521,"domain_scores_codex":[0.9998866,0.00001881281,0.00002270225,0.00002087215,0.00003597371,0.00001501737],"domain_scores_gemma":[0.9999067,0.0000154745,0.00001998795,0.00002251143,0.00001218167,0.00002316112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001087684,0.00003842251,0.0001635774,0.00002822115,0.000005334333,0.00003102258,0.00002540411,0.0001328316,0.9964789,0.0002010253,0.00006912109,0.002717361],"study_design_scores_gemma":[0.00002562245,0.0002222603,0.001524583,0.00001059574,0.00001497126,0.0001351671,0.0000189067,0.0006992146,0.9914696,0.00007166174,0.00580448,0.000002790774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531661,0.001796783,0.03640278,0.000194569,0.0001090749,0.0004605095,0.001496498,0.0004782188,0.005895516],"genre_scores_gemma":[0.9437375,0.002759446,0.04172903,0.0001471238,0.00002562724,0.0003439114,0.002500525,0.0001938763,0.00856291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458044,"threshold_uncertainty_score":0.004877687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085835369493848,"score_gpt":0.2549220025396759,"score_spread":0.2340636488447374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}