{"id":"W2132058335","doi":"10.1111/j.1524-4733.2009.00595.x","title":"Using the Incremental Net Benefit Framework for Quantitative Benefit–Risk Analysis in Regulatory Decision-Making—A Case Study of Alosetron in Irritable Bowel Syndrome","year":2009,"lang":"en","type":"article","venue":"Value in Health","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of British Columbia","funders":"","keywords":"Medicine; Irritable bowel syndrome; Placebo; Relative risk; Confidence interval; Meta-analysis; Internal medicine; Decision analysis; Statistics; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01640315,0.00123659,0.001259297,0.001553945,0.0009520362,0.004408999,0.001823435,0.002545957,0.005006164],"category_scores_gemma":[0.03461886,0.0006550921,0.001209785,0.001445176,0.002228682,0.00460903,0.001858511,0.003164186,0.0002176355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003448035,"about_ca_system_score_gemma":0.002698709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006880645,"about_ca_topic_score_gemma":0.00690056,"domain_scores_codex":[0.9904784,0.008143641,0.000180899,0.0002733724,0.0006243619,0.0002993065],"domain_scores_gemma":[0.9527583,0.04502534,0.0005605906,0.0005508498,0.0008682034,0.0002366832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003209744,0.0002797791,0.002536945,0.0002198,0.0001916693,0.0004927229,0.0004378746,0.6180523,0.0005630744,0.3198128,0.001441912,0.05565018],"study_design_scores_gemma":[0.00006664137,0.0001698298,0.0006232189,0.00006083555,0.00009791929,0.0001691258,0.0002378891,0.7785693,0.0003348161,0.2174993,0.002118031,0.00005317447],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1465382,0.001976189,0.8088152,0.005767615,0.000157754,0.0005764975,0.0002906764,0.0001451,0.03573268],"genre_scores_gemma":[0.9002916,0.0005219138,0.09655895,0.0001307267,0.00005470353,0.0001721163,0.00005376572,0.00003864111,0.002177572],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01640315,"threshold_uncertainty_score":0.0867492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3299377744357388,"score_gpt":0.4681184910952925,"score_spread":0.1381807166595537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}