{"id":"W2132061959","doi":"10.1161/circresaha.110.230888","title":"The Ras Activator RasGRP3 Mediates Diabetes-Induced Embryonic Defects and Affects Endothelial Cell Migration","year":2011,"lang":"en","type":"article","venue":"Circulation Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute","keywords":"MAPK/ERK pathway; Biology; Cell biology; Activator (genetics); Signal transduction; Embryonic stem cell; Endocrinology; Internal medicine; Immunology; Medicine; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001531005,0.0005096083,0.0001714092,0.000325087,0.0002001955,0.0002250719,0.000376971,0.0003073352,0.001449351],"category_scores_gemma":[0.0001585289,0.0001415091,0.0002655661,0.0001302706,0.0003480767,0.0001457636,0.00026073,0.0007644322,0.0003717855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003943923,"about_ca_system_score_gemma":0.0002322145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004409851,"about_ca_topic_score_gemma":0.0005599588,"domain_scores_codex":[0.9998786,0.00001799974,0.00001259614,0.0000224281,0.00003578297,0.00003256787],"domain_scores_gemma":[0.9998247,0.00003176952,0.00006883946,0.00001993069,0.000009928658,0.00004480208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002237812,0.00003092948,0.0006064016,0.00004262796,0.000005335042,0.0002676301,0.00001153702,0.0001059145,0.9972854,0.0001918469,0.00004282297,0.001185846],"study_design_scores_gemma":[0.00002705468,0.00025675,0.007862203,0.000008769414,0.00002794742,0.0007459106,0.00003313184,0.0008413012,0.9887456,0.00007927098,0.001367374,0.000004583468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948671,0.0007512049,0.00251859,0.0001248378,0.00002289877,0.00002086978,0.0003119034,0.0001147146,0.001267868],"genre_scores_gemma":[0.9959748,0.0007871756,0.001589376,0.0000388382,0.000008111107,0.00002527961,0.0002331206,0.00001985664,0.001323502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449351,"threshold_uncertainty_score":0.00484854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04283467870681534,"score_gpt":0.292127773677478,"score_spread":0.2492930949706627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}