{"id":"W2132069074","doi":"10.1194/jlr.m034132","title":"Rare APOA5 promoter variants associated with paradoxical HDL cholesterol decrease in response to fenofibric acid therapy","year":2013,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Dyslipidemia; Medicine; Internal medicine; Cholesterol; Endocrinology; Cholesterylester transfer protein; Fenofibrate; Combination therapy; Pharmacology; Lipoprotein; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009251923,0.0001694196,0.0006312807,0.0007505433,0.0001057495,0.0001079081,0.0002586742,0.0001720949,0.000334718],"category_scores_gemma":[0.002266297,0.0001027688,0.0001958443,0.001040542,0.0000822353,0.0002357439,0.00006478985,0.001191049,0.00008359932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003693009,"about_ca_system_score_gemma":0.001264401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001697914,"about_ca_topic_score_gemma":0.00002049232,"domain_scores_codex":[0.9943955,0.001911466,0.0005795092,0.0002607943,0.002145459,0.0007073038],"domain_scores_gemma":[0.9969512,0.0002535327,0.0001336917,0.0004943393,0.001086857,0.001080344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.09372874,0.007733376,0.1969908,0.0003763017,0.002379163,0.007616471,0.006974356,0.00005046923,0.3700874,0.00001927741,0.02002037,0.2940233],"study_design_scores_gemma":[0.008854045,0.006583444,0.9732158,0.0009756199,0.00001916275,0.0009743032,0.0001701227,0.00004398938,0.004738051,0.00005013452,0.004227578,0.0001477848],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872136,0.0004235609,0.00007156085,0.01059419,0.00007344763,0.00140508,0.000002482439,0.00001064236,0.0002054802],"genre_scores_gemma":[0.9973069,0.0001552053,0.0005285783,0.0006797694,0.0006489176,0.00006383842,0.00000207016,0.00004166989,0.0005729846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.776225,"threshold_uncertainty_score":0.517458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05570764879638716,"score_gpt":0.351594409564137,"score_spread":0.2958867607677498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}