{"id":"W2132085997","doi":"10.1242/dev.117978","title":"Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Jane Coffin Childs Memorial Fund for Medical Research; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Biology; Orexin; Induced pluripotent stem cell; Neuropeptide; Neuroscience; Cellular differentiation; Oxytocin; Melanin-concentrating hormone; Directed differentiation; Neural stem cell; Stem cell; Vasopressin; Hypothalamus; Cell type; Cell biology; Cell; Endocrinology; Embryonic stem cell; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003181563,0.0002708787,0.000202527,0.0002205424,0.0001062331,0.0002461929,0.000215509,0.0002376178,0.001695515],"category_scores_gemma":[0.0002283673,0.0001472818,0.0002446586,0.0002158193,0.0001729795,0.000126123,0.0002227275,0.0004182828,0.000531379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009844876,"about_ca_system_score_gemma":0.0001672486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001497341,"about_ca_topic_score_gemma":0.0003302704,"domain_scores_codex":[0.9998574,0.0000220795,0.00002710639,0.00002468428,0.00005215067,0.0000165036],"domain_scores_gemma":[0.9999214,0.00002404821,0.0000158016,0.00001476528,0.00001402561,0.000009867419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000643898,0.0000264705,0.0003050711,0.0001023145,0.00001855962,0.0001694576,0.00004138536,0.000557386,0.9871848,0.001148564,0.0002408485,0.01014064],"study_design_scores_gemma":[0.00004654424,0.0002656675,0.001418857,0.00001956578,0.00004877082,0.0004105744,0.00002922884,0.002390694,0.9824479,0.0004159317,0.01249671,0.000009723024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8308563,0.003638424,0.1414336,0.000413432,0.0004322843,0.001194272,0.006957327,0.0005791042,0.01449526],"genre_scores_gemma":[0.9211706,0.002777796,0.06209802,0.0002095853,0.00005057147,0.0004961876,0.006467354,0.00007692278,0.006652975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695515,"threshold_uncertainty_score":0.005672038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2032741779964707,"score_gpt":0.266994082176374,"score_spread":0.06371990417990331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}