{"id":"W2132087763","doi":"10.1091/mbc.e14-04-0947","title":"Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair","year":2014,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Sydney Medical School; National Health and Medical Research Council; Medical Research Council; University of Sydney; Canadian Institutes of Health Research; Cancer Institute NSW; Ian Potter Foundation; David and Elaine Potter Foundation; Jain Foundation; Children's Medical Research","keywords":"Dysferlin; Calpain; Biology; Cell biology; Transmembrane protein; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005725226,0.0001994933,0.0002277731,0.00004727351,0.0001181026,0.0000064081,0.0002631521,0.0003323616,0.000009945496],"category_scores_gemma":[0.0002573343,0.0001495319,0.0003683381,0.00009212291,0.0002403126,0.000002203566,0.0001331548,0.0001021174,0.000004905229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001412905,"about_ca_system_score_gemma":0.00004938626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002324955,"about_ca_topic_score_gemma":0.0000175234,"domain_scores_codex":[0.9985126,0.0003657778,0.0003315898,0.0004493328,0.00009472148,0.0002460385],"domain_scores_gemma":[0.9989018,0.00004009878,0.0002095164,0.0006839308,0.0000943844,0.00007020132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002402933,0.00009067579,0.0003159214,0.00008526797,0.00006139436,5.01671e-7,0.00001674276,0.0006874273,0.9954554,0.0007462543,0.001758756,0.0005413758],"study_design_scores_gemma":[0.0008683341,0.0005076793,0.0001715959,0.00002025264,0.00005440818,0.000008640616,0.00002037824,0.003192666,0.9558761,0.0005785848,0.03850969,0.000191667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9234833,0.0005736517,0.07375685,0.0003371327,0.0005683057,0.0006707021,0.00003000306,0.0000418215,0.0005382361],"genre_scores_gemma":[0.9928371,0.00001942747,0.003174656,0.0008203739,0.0001253134,0.00006531661,0.0001988266,0.00003489726,0.002724083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0705822,"threshold_uncertainty_score":0.6097736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004954103054748516,"score_gpt":0.2173694284918883,"score_spread":0.2124153254371398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}