{"id":"W2132088083","doi":"10.1073/pnas.1414221111","title":"(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of <i>Plasmodium</i>","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute of General Medical Sciences; U.S. Public Health Service; Howard Hughes Medical Institute","keywords":"Host (biology); Malaria; Plasmodium falciparum; Plasmodium (life cycle); Immunology; Biology; Virology; Medicine; Computer science; Parasite hosting; World Wide Web; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597288,0.0003109071,0.0003529038,0.0002208545,0.0002233844,0.0003245512,0.0002467562,0.0004549463,0.002733611],"category_scores_gemma":[0.0001605108,0.0001009482,0.0001891674,0.0002550888,0.0002787561,0.0001787835,0.0001500619,0.0006172807,0.0006776946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002857173,"about_ca_system_score_gemma":0.0005058349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007725736,"about_ca_topic_score_gemma":0.00244851,"domain_scores_codex":[0.9999353,0.00001364888,0.000006495439,0.000008756739,0.00001702038,0.0000188362],"domain_scores_gemma":[0.999935,0.000008268365,0.00001538486,0.000004507822,0.000009956998,0.00002675664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007775985,0.001726545,0.0032213,0.0006794875,0.0001064938,0.002932419,0.0001098986,0.001507668,0.8281892,0.003907043,0.008890825,0.1409531],"study_design_scores_gemma":[0.00937768,0.08613759,0.026057,0.0001244909,0.0003234084,0.02199059,0.000177437,0.003627265,0.6887231,0.001946258,0.1614019,0.0001132935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634414,0.0138628,0.003035392,0.002620625,0.0003749898,0.0006445531,0.001339364,0.000355167,0.01432576],"genre_scores_gemma":[0.9866551,0.003861868,0.002494696,0.0007844476,0.0001019628,0.0001352745,0.001314642,0.00002532823,0.004626635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002733611,"threshold_uncertainty_score":0.009144843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08467842223777292,"score_gpt":0.3766031426012992,"score_spread":0.2919247203635263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}