{"id":"W2132088083","doi":"10.1073/pnas.1414221111","title":"(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of <i>Plasmodium</i>","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute of General Medical Sciences; U.S. Public Health Service; Howard Hughes Medical Institute","keywords":"Host (biology); Malaria; Plasmodium falciparum; Plasmodium (life cycle); Immunology; Biology; Virology; Medicine; Computer science; Parasite hosting; World Wide Web; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003725422,0.0001137414,0.0003948818,0.0001297262,0.0001187798,0.00001765493,0.0007187017,0.0001511059,0.00002272305],"category_scores_gemma":[0.006271337,0.00007294367,0.0001529067,0.000636087,0.0007097602,0.0003143201,0.0001346802,0.0002752117,0.00000300399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002414473,"about_ca_system_score_gemma":0.0001531348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001312951,"about_ca_topic_score_gemma":2.859495e-7,"domain_scores_codex":[0.9974135,0.00002093691,0.0005079219,0.0003209837,0.001448763,0.0002879147],"domain_scores_gemma":[0.9980476,0.0006441139,0.0004788817,0.00002193554,0.0006762965,0.0001311716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003742629,0.0004905254,0.02170393,0.0007447641,0.0001894429,3.385958e-8,0.0004676108,0.00001909687,0.8000613,0.1556245,0.01419493,0.002761184],"study_design_scores_gemma":[0.00404333,0.001543099,0.3626727,0.0005527441,0.00007624449,0.00001034222,0.0001844595,0.002944721,0.604098,0.01335189,0.01033096,0.0001914776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9313664,0.000117371,0.00003410134,0.06020803,0.00006315569,0.001238964,0.0001048907,0.00001680686,0.006850323],"genre_scores_gemma":[0.9944559,0.00006162886,0.003016832,0.002096772,0.000166018,0.00004125171,6.875026e-7,0.000007163622,0.0001537752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3409688,"threshold_uncertainty_score":0.7507828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08467842223777292,"score_gpt":0.3766031426012992,"score_spread":0.2919247203635263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}