{"id":"W2132090254","doi":"10.1158/1535-7163.mct-07-0560","title":"Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Romidepsin; Cancer research; Histone deacetylase; Histone deacetylase inhibitor; Biology; Cell growth; Cell cycle; Propidium iodide; Cell cycle checkpoint; Vorinostat; Apoptosis; Molecular biology; Programmed cell death; Histone; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001478235,0.0003041068,0.000252978,0.0001733343,0.0001508481,0.00002601168,0.0002288617,0.0002945023,0.000008638477],"category_scores_gemma":[0.00001431488,0.0003303195,0.0001009428,0.0002618051,0.0002249056,0.00001630626,0.0001522416,0.0003380556,0.000005797321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001669771,"about_ca_system_score_gemma":0.0001993686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003325381,"about_ca_topic_score_gemma":0.00008993589,"domain_scores_codex":[0.9980126,0.0001893491,0.0003399191,0.0005939623,0.0003855427,0.000478619],"domain_scores_gemma":[0.9991817,0.00001299571,0.0001057981,0.0004149368,0.0001284572,0.00015609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001714829,0.000203662,0.0008791287,0.00004353137,0.00004763868,0.00002369815,0.0003973137,0.0003646743,0.9964107,0.00005706461,0.0003865831,0.001014527],"study_design_scores_gemma":[0.00135757,0.0002089155,0.0006408984,0.00002965584,0.00002585464,0.0000127758,0.00004520099,0.001006726,0.9944224,0.000114669,0.001751071,0.0003842793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894666,0.00759919,0.001636717,0.0003245075,0.000188282,0.0003526273,0.00002027176,0.00002389118,0.0003878845],"genre_scores_gemma":[0.9946911,0.003776913,0.000336489,0.0005710125,0.000136931,0.00009168184,0.00006647243,0.00008439692,0.0002450458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00522443,"threshold_uncertainty_score":0.9999149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262670536116556,"score_gpt":0.2778218901854587,"score_spread":0.2551951848242931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}