{"id":"W2132117638","doi":"10.1016/j.immuni.2014.10.021","title":"Noncanonical Mode of ERK Action Controls Alternative αβ and γδ T Cell Lineage Fates","year":2014,"lang":"en","type":"article","venue":"Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Krembil Foundation; Deutsche Forschungsgemeinschaft","keywords":"MAPK/ERK pathway; Cell biology; Biology; Mode of action; Kinase; Cell fate determination; Extracellular; Genetics; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002319076,0.0003200709,0.0002009034,0.0002461427,0.000307756,0.0009139494,0.0003189292,0.0002306736,0.002602061],"category_scores_gemma":[0.0002509424,0.0001514882,0.0002022449,0.0001196279,0.0003060216,0.0005950068,0.0004333965,0.000805256,0.0006916259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639314,"about_ca_system_score_gemma":0.0002860386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001576953,"about_ca_topic_score_gemma":0.0005121007,"domain_scores_codex":[0.9996697,0.00003807279,0.00001990599,0.0000662743,0.00006435377,0.0001416874],"domain_scores_gemma":[0.9998391,0.00002279965,0.00003055644,0.00003156158,0.00003673427,0.00003935754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000601958,0.0000530059,0.001987776,0.00006535619,0.000008567072,0.0002153709,0.00005819873,0.0002387852,0.9848091,0.004168095,0.0002198098,0.007574051],"study_design_scores_gemma":[0.00003365347,0.0001457498,0.01611806,0.00002020016,0.00002128969,0.000904382,0.0003167277,0.004276817,0.9709302,0.002133694,0.00508478,0.00001435989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900042,0.0007926179,0.003622371,0.0001097934,0.00005952588,0.00001033025,0.0001994332,0.00009065885,0.005111095],"genre_scores_gemma":[0.9965259,0.0002486701,0.000914535,0.00002247813,0.000009434091,0.000007569143,0.000122581,0.0000210159,0.00212788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002602061,"threshold_uncertainty_score":0.008704782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556355780673636,"score_gpt":0.2618133725223105,"score_spread":0.2462498147155741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}