{"id":"W2132127856","doi":"10.1124/mol.105.019844","title":"Molecular Determinants in the Second Intracellular Loop of the 5-Hydroxytryptamine-1A Receptor for G-Protein Coupling","year":2006,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Mental Health","keywords":"G protein-coupled receptor; Biophysics; G protein; Chemistry; Receptor; Allosteric regulation; Signal transduction; Adenylyl cyclase; Agonist; Protein subunit; Stereochemistry; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005863777,0.0002594136,0.0002757485,0.0000636925,0.0001077461,0.00002017219,0.0006686011,0.0002565807,0.0001685515],"category_scores_gemma":[0.0000405783,0.00019087,0.0002634049,0.0002006204,0.0001384275,0.00000514424,0.0001357688,0.0002111703,0.000003165919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002257309,"about_ca_system_score_gemma":0.00008456166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002677059,"about_ca_topic_score_gemma":0.00003120617,"domain_scores_codex":[0.9982146,0.000200737,0.0004792108,0.0004469558,0.0002010614,0.0004574116],"domain_scores_gemma":[0.9991884,0.00002880168,0.0002320551,0.0004086152,0.000101215,0.00004092768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000917289,0.0001188986,0.0001515156,0.0000585696,0.00003920626,0.00001958541,0.00002350192,0.002375513,0.9959001,0.0004342807,0.0005964858,0.0001906246],"study_design_scores_gemma":[0.00121507,0.0002146676,0.00003676449,0.00001910001,0.00004412138,0.00001441772,0.00004685007,0.002475425,0.9835988,0.0003879063,0.01172581,0.0002210735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871707,0.001354048,0.009509147,0.0002733052,0.0003878484,0.001157722,0.00003359229,0.000007537592,0.000106129],"genre_scores_gemma":[0.9978463,0.00001146021,0.0006172794,0.0006851804,0.0001821713,0.0002567597,0.00003908932,0.00004781996,0.000313938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0123013,"threshold_uncertainty_score":0.7783455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006943933593932165,"score_gpt":0.249079685781545,"score_spread":0.2421357521876129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}