{"id":"W2132140476","doi":"10.1371/journal.pone.0008471","title":"A Direct Phenotypic Comparison of siRNA Pools and Multiple Individual Duplexes in a Functional Assay","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Small interfering RNA; RNA interference; Phenotype; Biology; Computational biology; Duplex (building); RNA; Gene knockdown; Function (biology); Genetics; Cell biology; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00340595,0.001092472,0.0008286886,0.001753638,0.0005099127,0.0007096613,0.0006184251,0.001037759,0.002365142],"category_scores_gemma":[0.002719024,0.0004999857,0.0009120161,0.0006917798,0.000866394,0.0006147971,0.0008501488,0.001109735,0.001184106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004735272,"about_ca_system_score_gemma":0.0003955523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004954484,"about_ca_topic_score_gemma":0.0007817929,"domain_scores_codex":[0.9957249,0.0008887121,0.0006527469,0.001145014,0.001372701,0.000215956],"domain_scores_gemma":[0.9950984,0.002034529,0.0007442837,0.0007873455,0.00107934,0.0002561435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000514935,0.0000598173,0.0004912133,0.00006968392,0.00001961621,0.00002492134,0.00002679002,0.00007407727,0.9977965,0.00004511622,0.00004187055,0.001298896],"study_design_scores_gemma":[0.000009435194,0.001082287,0.006106367,0.000009376012,0.00007319081,0.00029519,0.00004194313,0.001008273,0.9901953,0.00005363274,0.001108687,0.00001623373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8052142,0.001298119,0.1826681,0.0002197952,0.0002443955,0.001343104,0.00299027,0.001253784,0.004768207],"genre_scores_gemma":[0.8668461,0.0009513502,0.1192786,0.0003845753,0.00006117559,0.002474963,0.00427505,0.0005425786,0.005185601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00340595,"threshold_uncertainty_score":0.01801258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05018323159754969,"score_gpt":0.2528189048113038,"score_spread":0.2026356732137541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}