{"id":"W2132140476","doi":"10.1371/journal.pone.0008471","title":"A Direct Phenotypic Comparison of siRNA Pools and Multiple Individual Duplexes in a Functional Assay","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Small interfering RNA; RNA interference; Phenotype; Biology; Computational biology; Duplex (building); RNA; Gene knockdown; Function (biology); Genetics; Cell biology; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000962749,0.00008111772,0.0001694178,0.00004572722,0.00002003854,0.00001011138,0.00007027348,0.00007935816,0.0000159851],"category_scores_gemma":[0.00009605179,0.00007929385,0.00002736032,0.0000505287,0.00002546096,0.000003843898,0.00003485137,0.00006149047,0.000003471615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004338789,"about_ca_system_score_gemma":0.00002028077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002596463,"about_ca_topic_score_gemma":0.00008742684,"domain_scores_codex":[0.9993863,0.00003444903,0.0001642826,0.0001764449,0.0001226859,0.0001158783],"domain_scores_gemma":[0.9997358,0.00002076244,0.00005356635,0.0001139717,0.0000441317,0.00003180666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001325226,0.0007151324,0.1026531,0.00001187869,0.00007642287,5.439258e-7,0.00008772588,0.00002036552,0.8943091,0.000008535195,0.0002478597,0.001736849],"study_design_scores_gemma":[0.0004814847,0.0005709977,0.1904619,0.0000457599,0.00002959672,6.145206e-7,0.00005363654,0.0002837978,0.8078861,0.00003924891,0.00004992058,0.0000969537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983385,0.000834774,0.00004325017,0.00006896834,0.00001334586,0.0000946636,0.00001973831,0.000004994599,0.000581833],"genre_scores_gemma":[0.9992402,0.00005778447,0.0003049684,0.0001140091,0.0000634339,0.000004500735,0.00007436723,0.000004737286,0.0001360194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08780883,"threshold_uncertainty_score":0.323351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05018323159754969,"score_gpt":0.2528189048113038,"score_spread":0.2026356732137541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}