{"id":"W2132142991","doi":"10.1371/journal.pone.0011296","title":"A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Medical Research Council; Multiple Sclerosis Society; National Institute of Neurological Disorders and Stroke; Massachusetts General Hospital; National Institute for Health and Care Research; Broad Institute; University of California, San Francisco; Vanderbilt University Medical Center; Massachusetts Institute of Technology; University of Miami; Wellcome Trust; Vanderbilt University; Brigham and Women's Hospital; Harvard University; National Multiple Sclerosis Society","keywords":"Single-nucleotide polymorphism; Human leukocyte antigen; SNP; Haplotype; Major histocompatibility complex; Allele; Genetics; Biology; Locus (genetics); Tag SNP; Gene; Genotype; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003499871,0.0006187037,0.0009341963,0.0006700353,0.0005599908,0.001138908,0.0006959437,0.0006020342,0.005803401],"category_scores_gemma":[0.006856355,0.0003715687,0.001361659,0.00178835,0.0004422739,0.0002651883,0.0006255998,0.0008146647,0.0008180766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509799,"about_ca_system_score_gemma":0.0005755962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002682075,"about_ca_topic_score_gemma":0.00171457,"domain_scores_codex":[0.9968992,0.0007570434,0.0003119345,0.001587545,0.0002272493,0.0002169464],"domain_scores_gemma":[0.9946977,0.002192362,0.001512586,0.0009455057,0.0002387988,0.0004130459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003864847,0.0001462675,0.9664884,0.0001892205,0.002145736,0.0004395395,0.0001583473,0.0004846356,0.01183461,0.0001609058,0.0007993202,0.01328815],"study_design_scores_gemma":[0.0002516855,0.0003038091,0.9915298,0.00004897603,0.001474529,0.001465006,0.00005882102,0.001559673,0.001581696,0.0005005006,0.001210687,0.00001473021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950955,0.001365278,0.001207044,0.0001242897,0.00002592071,0.0000297066,0.001543808,0.0000376609,0.000570698],"genre_scores_gemma":[0.9969931,0.0001973165,0.000820045,0.00005844898,0.0000255439,0.00003051253,0.001607041,0.00001381204,0.0002541646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005803401,"threshold_uncertainty_score":0.01941431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09968988456211138,"score_gpt":0.2872261789936585,"score_spread":0.1875362944315471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}