{"id":"W2132142991","doi":"10.1371/journal.pone.0011296","title":"A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Medical Research Council; Multiple Sclerosis Society; National Institute of Neurological Disorders and Stroke; Massachusetts General Hospital; National Institute for Health and Care Research; Broad Institute; University of California, San Francisco; Vanderbilt University Medical Center; Massachusetts Institute of Technology; University of Miami; Wellcome Trust; Vanderbilt University; Brigham and Women's Hospital; Harvard University; National Multiple Sclerosis Society","keywords":"Single-nucleotide polymorphism; Human leukocyte antigen; SNP; Haplotype; Major histocompatibility complex; Allele; Genetics; Biology; Locus (genetics); Tag SNP; Gene; Genotype; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001152748,0.0004842857,0.001337757,0.0002705235,0.0003667409,0.0001050063,0.0005486381,0.000341749,0.00165135],"category_scores_gemma":[0.0104558,0.0004359401,0.0002618245,0.0005490837,0.0005186384,0.0001885336,0.0006667948,0.001388779,0.0007511749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006058693,"about_ca_system_score_gemma":0.0002347704,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004971209,"about_ca_topic_score_gemma":0.0264241,"domain_scores_codex":[0.9948458,0.0002278236,0.000877856,0.001326228,0.001692948,0.001029337],"domain_scores_gemma":[0.994654,0.001303354,0.0001782716,0.001956445,0.001043973,0.0008639735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008122547,0.003853315,0.4389158,0.0001372743,0.0005442841,0.000005881755,0.0002669277,6.609081e-7,0.5523662,0.00001049848,0.001648362,0.001438606],"study_design_scores_gemma":[0.005368578,0.0003521549,0.7897452,0.0003580957,0.0002785168,4.774017e-7,0.0001534095,0.0006851528,0.2019757,0.0001452588,0.0005974209,0.0003400482],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881494,0.0002000637,0.0001607082,0.005322009,0.0002070954,0.004318626,0.000660677,0.0003302534,0.0006511424],"genre_scores_gemma":[0.9906886,0.0000426164,0.006851192,0.0006954354,0.0004174479,0.00064678,0.0001421128,0.00006915567,0.0004466218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3508294,"threshold_uncertainty_score":0.9998093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09968988456211138,"score_gpt":0.2872261789936585,"score_spread":0.1875362944315471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}