{"id":"W2132169173","doi":"10.2337/diabetes.50.10.2376","title":"High Glucose–Enhanced Mesangial Cell Extracellular Signal–Regulated Protein Kinase Activation and α1(IV) Collagen Expression in Response to Endothelin-1","year":2001,"lang":"en","type":"article","venue":"Diabetes","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Calphostin; Protein kinase C; Calphostin C; Mesangial cell; Endothelin 1; Signal transduction; Protein kinase A; Extracellular; Kinase; Molecular biology; Chemistry; Autocrine signalling; Endocrinology; Biology; Cell biology; Internal medicine; Biochemistry; Medicine; Receptor; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060979,0.0004982938,0.0003330199,0.0002162105,0.0001231888,0.0002847597,0.0001039645,0.0002028726,0.001010371],"category_scores_gemma":[0.00007008792,0.000166287,0.0003525628,0.0001864971,0.0002144516,0.0001621515,0.0001500416,0.0006014999,0.0002194904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004330911,"about_ca_system_score_gemma":0.0001737839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00186701,"about_ca_topic_score_gemma":0.002745906,"domain_scores_codex":[0.9998052,0.00003458583,0.00001384591,0.00002648446,0.00004520161,0.00007480277],"domain_scores_gemma":[0.999923,0.000008611504,0.00001624404,0.00000849018,0.000009147075,0.00003454175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002102139,0.00002481802,0.0001416906,0.00001906653,0.000003697695,0.0000417337,0.0000083798,0.00002789125,0.9991843,0.00001606046,0.00001807367,0.0003040313],"study_design_scores_gemma":[0.00002190685,0.0003001257,0.02823318,0.000003806492,0.00001709425,0.0001849545,0.0000464269,0.0005418382,0.969924,0.0000201196,0.000699527,0.000007012435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976227,0.0008802447,0.0005283642,0.00005418871,0.00002779056,0.00001210708,0.0002715396,0.00002883265,0.0005741666],"genre_scores_gemma":[0.9956036,0.0006707923,0.001055957,0.00007206383,0.00001901154,0.00003267605,0.0005770593,0.000009681977,0.001959293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186701,"threshold_uncertainty_score":0.003712237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007142404384684591,"score_gpt":0.2269222980670242,"score_spread":0.2197798936823397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}