{"id":"W2132169173","doi":"10.2337/diabetes.50.10.2376","title":"High Glucose–Enhanced Mesangial Cell Extracellular Signal–Regulated Protein Kinase Activation and α1(IV) Collagen Expression in Response to Endothelin-1","year":2001,"lang":"en","type":"article","venue":"Diabetes","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Calphostin; Protein kinase C; Calphostin C; Mesangial cell; Endothelin 1; Signal transduction; Protein kinase A; Extracellular; Kinase; Molecular biology; Chemistry; Autocrine signalling; Endocrinology; Biology; Cell biology; Internal medicine; Biochemistry; Medicine; Receptor; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004011242,0.0002712517,0.0004036752,0.0003043422,0.00008589096,0.00004273936,0.00009489366,0.0001680056,0.0004389269],"category_scores_gemma":[0.0004063964,0.0002495859,0.00007350064,0.0004377119,0.00005489747,0.0001652348,0.00006866019,0.0001165153,0.00005885582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001586224,"about_ca_system_score_gemma":0.000206048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002293554,"about_ca_topic_score_gemma":0.000001947341,"domain_scores_codex":[0.9981133,0.0001988715,0.0003619594,0.0004916262,0.0003181248,0.0005161659],"domain_scores_gemma":[0.9988034,0.0002272654,0.00009891464,0.0003501282,0.00009194037,0.0004283294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002388412,0.0003620174,0.003351914,0.0001320887,0.00001866607,0.00004520303,0.0003179896,0.00004137366,0.9901601,0.000007990533,0.0002381314,0.00293612],"study_design_scores_gemma":[0.00462862,0.0004389302,0.01467994,0.0006202828,0.00004409264,5.12738e-7,0.0001299579,0.0003418826,0.9772903,0.0001996443,0.001352776,0.0002731099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958497,0.001481043,0.0001145015,0.0007288232,0.00004565345,0.001512155,0.00003127268,0.0001034264,0.000133482],"genre_scores_gemma":[0.9966178,0.00002505517,0.0006826721,0.0003470204,0.0001245578,0.0002359177,0.00009001385,0.00004782444,0.001829155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01286984,"threshold_uncertainty_score":0.9999956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007142404384684591,"score_gpt":0.2269222980670242,"score_spread":0.2197798936823397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}