{"id":"W2132176606","doi":"10.1016/j.celrep.2012.01.006","title":"Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels","year":2012,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Centre National de la Recherche Scientifique; Fondation de France; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Mechanotransduction; Apoptosis; Cell biology; Polycystic kidney disease; PKD1; Mechanosensitive channels; Autosomal dominant polycystic kidney disease; Knockout mouse; Kidney; Biology; In vivo; Internal medicine; Chemistry; Endocrinology; Medicine; Ion channel; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290269,0.0002796644,0.0002737934,0.0001724382,0.0001261754,0.0003592904,0.0001481676,0.0003050809,0.0006629015],"category_scores_gemma":[0.000242534,0.00009798702,0.0002287842,0.00008988258,0.0003851712,0.0003299885,0.0002543516,0.0003390218,0.0001289567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001358828,"about_ca_system_score_gemma":0.000131301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008595097,"about_ca_topic_score_gemma":0.000114697,"domain_scores_codex":[0.9998187,0.00004302381,0.00002154783,0.00002646134,0.00005365523,0.0000365788],"domain_scores_gemma":[0.9998288,0.00002938947,0.00006603083,0.00002134631,0.00002179947,0.00003259736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00012855,0.00001779997,0.0002789838,0.00005744658,0.000009541696,0.00008242422,0.00001535229,0.00003625703,0.9977376,0.00008546179,0.00002804097,0.001522554],"study_design_scores_gemma":[0.00004012118,0.0007102407,0.01626811,0.000008359647,0.00002059004,0.0009260115,0.00005091575,0.0004461505,0.97971,0.0001922658,0.001620052,0.000007252971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935842,0.00309846,0.002177963,0.0001683745,0.00004205567,0.00001391614,0.00007160832,0.00007288132,0.0007704726],"genre_scores_gemma":[0.9972085,0.001234801,0.0009007845,0.00004456688,0.00001615105,0.00001477467,0.00007306371,0.000006522458,0.0005007695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006629015,"threshold_uncertainty_score":0.002217591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015429686249649,"score_gpt":0.2297953791158216,"score_spread":0.2196410822533251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}