{"id":"W2132212967","doi":"10.1158/0008-5472.can-10-4610","title":"Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute","keywords":"LNCaP; Protein kinase B; Cancer research; Tumor progression; DU145; Prostate cancer; PI3K/AKT/mTOR pathway; Hyaluronic acid; Angiogenesis; Metastasis; Cancer; Downregulation and upregulation; Biology; Chemistry; Signal transduction; Medicine; Internal medicine; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001243113,0.000249436,0.0003411318,0.000250052,0.0001702142,0.0000311298,0.0005865997,0.0001671162,0.0003323829],"category_scores_gemma":[0.0001051458,0.0002230745,0.0001140434,0.0005856075,0.0003989709,0.00002070891,0.0002499461,0.0004714396,0.000003846713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002069571,"about_ca_system_score_gemma":0.001618041,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01432362,"about_ca_topic_score_gemma":0.003259441,"domain_scores_codex":[0.9969626,0.0003044101,0.0003357494,0.00074789,0.0004882499,0.00116107],"domain_scores_gemma":[0.9984773,0.00003782252,0.0001214482,0.0004855999,0.0006961377,0.0001816488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002645442,0.0002192074,0.007257937,0.0002231165,0.00008431416,0.00001090254,0.0002991196,0.0001269884,0.961376,0.00001590966,0.001087614,0.02665347],"study_design_scores_gemma":[0.00187041,0.0007458741,0.002808494,0.0001059901,0.000005867064,7.160959e-7,0.00008369194,0.0002935694,0.9834003,0.00005392432,0.01037218,0.0002590157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851302,0.01182758,0.00007599908,0.0002512968,0.0001646597,0.001843367,0.0005024447,0.0000112914,0.0001931807],"genre_scores_gemma":[0.981382,0.01366596,0.0001642171,0.00003953174,0.0001939399,0.003112174,0.000036283,0.00006947583,0.001336389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02639445,"threshold_uncertainty_score":0.9922401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08190990194604485,"score_gpt":0.3870912419041421,"score_spread":0.3051813399580973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}