{"id":"W2132268633","doi":"10.1158/1078-0432.ccr-06-0812","title":"The Combi-Targeting Concept: <i>In vitro</i> and <i>In vivo</i> Fragmentation of a Stable Combi-Nitrosourea Engineered to Interact with the Epidermal Growth Factor Receptor while Remaining DNA Reactive","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cyclization and Aryne Chemistry","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Health Canada; Royal Victoria Hospital; Royal Victoria Regional Health Centre","funders":"Cancer Research Society","keywords":"In vivo; DU145; Comet assay; Molecular biology; Epidermal growth factor receptor; In vitro; Biology; Chemistry; DNA damage; Cancer cell; Biochemistry; Receptor; DNA; Cancer; LNCaP","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057601,0.0002693892,0.0001180619,0.00008793336,0.00005616782,0.0001460279,0.0001723101,0.0002619754,0.0007809399],"category_scores_gemma":[0.0001213004,0.00007125262,0.0001068676,0.00004900551,0.0001652131,0.0001860763,0.000105481,0.0002290734,0.0001986229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826689,"about_ca_system_score_gemma":0.00008540244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002025473,"about_ca_topic_score_gemma":0.0002224944,"domain_scores_codex":[0.9999442,0.000006663423,0.000002893092,0.00001946802,0.00001723347,0.000009485938],"domain_scores_gemma":[0.9999329,0.000008554823,0.00003227956,0.000007603747,0.00000871001,0.0000099872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004627864,0.00001721134,0.0000561854,0.00002367194,0.000002387495,0.00002112945,0.000005702337,0.00003732225,0.9985327,0.00005630416,0.00001544375,0.001185595],"study_design_scores_gemma":[0.00001119697,0.0004503507,0.0006306842,0.00000162728,0.000006435012,0.0002532766,0.00000383234,0.0004650688,0.9972796,0.0000142138,0.000882151,0.000001724757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922546,0.000838384,0.005269633,0.00004500732,0.00001542368,0.00005583965,0.00009085279,0.00005070202,0.001379512],"genre_scores_gemma":[0.9930462,0.000375209,0.004644381,0.00003054414,0.000005329211,0.00003707841,0.0001201402,0.000008414744,0.001732556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007809399,"threshold_uncertainty_score":0.002612531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05636942584909254,"score_gpt":0.3926558554273772,"score_spread":0.3362864295782847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}