{"id":"W2132268633","doi":"10.1158/1078-0432.ccr-06-0812","title":"The Combi-Targeting Concept: <i>In vitro</i> and <i>In vivo</i> Fragmentation of a Stable Combi-Nitrosourea Engineered to Interact with the Epidermal Growth Factor Receptor while Remaining DNA Reactive","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cyclization and Aryne Chemistry","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Health Canada; Royal Victoria Hospital; Royal Victoria Regional Health Centre","funders":"Cancer Research Society","keywords":"In vivo; DU145; Comet assay; Molecular biology; Epidermal growth factor receptor; In vitro; Biology; Chemistry; DNA damage; Cancer cell; Biochemistry; Receptor; DNA; Cancer; LNCaP","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002695003,0.0001680737,0.0003394308,0.00006115155,0.0001944924,0.0000725935,0.0003435311,0.0001310488,0.0002761353],"category_scores_gemma":[0.001460204,0.000112808,0.00006002008,0.0005041946,0.0003939435,0.0001254156,0.0001715336,0.001119253,0.000002439879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948127,"about_ca_system_score_gemma":0.0001641669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003796195,"about_ca_topic_score_gemma":0.0003550597,"domain_scores_codex":[0.9975034,0.000204933,0.0007459107,0.0004130544,0.0005523918,0.0005803106],"domain_scores_gemma":[0.9932834,0.005748175,0.0001921139,0.0002834313,0.0003029406,0.0001899277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00362804,0.000205733,0.03820371,0.0001270183,0.0000532244,0.00001198229,0.002721689,0.00006394796,0.9474578,0.00004627476,0.004829044,0.002651534],"study_design_scores_gemma":[0.002080082,0.00007663531,0.002997859,0.0003073479,0.000006734017,0.000001556963,0.006807792,0.0003095216,0.9800813,0.00003216902,0.007116157,0.0001828009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994318,0.0002959574,0.00009315185,0.002619362,0.00006733157,0.0002909681,0.00008269752,0.00001891718,0.002213601],"genre_scores_gemma":[0.9986957,0.0001755949,0.0001218842,0.0002672302,0.0001647542,0.00007069995,0.00002829602,0.00003074398,0.0004450871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03520584,"threshold_uncertainty_score":0.486266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05636942584909254,"score_gpt":0.3926558554273772,"score_spread":0.3362864295782847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}