{"id":"W2132276549","doi":"10.1002/med.10022","title":"Practice and principles of pharmacodynamic determination of HISS‐dependent and HISS‐independent insulin action: Methods to quantitate mechanisms of insulin resistance","year":2002,"lang":"en","type":"review","venue":"Medicinal Research Reviews","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Hiss; Endocrinology; Insulin; Internal medicine; Insulin resistance; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01391531,0.0004624552,0.003486297,0.00100279,0.000106612,0.000008766138,0.0003223668,0.000324192,0.0001944012],"category_scores_gemma":[0.005866809,0.0003354943,0.0002707823,0.0008539454,0.0004146002,0.0001500487,0.0003099063,0.001178634,0.00001847837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004387736,"about_ca_system_score_gemma":0.0004933884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006914038,"about_ca_topic_score_gemma":0.00004359314,"domain_scores_codex":[0.9908789,0.00442462,0.002117079,0.0007369025,0.001391222,0.0004513043],"domain_scores_gemma":[0.9941664,0.002515165,0.001475657,0.0005801711,0.0008120889,0.0004504765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005078301,0.000575815,0.000004134733,0.07953481,0.0002733371,0.0001435239,0.0003312082,8.903188e-8,0.001297075,0.0005195912,0.0001460018,0.9166666],"study_design_scores_gemma":[0.001650409,0.001717578,0.00007233238,0.03603166,0.003463474,0.0003365956,0.0001472733,0.00005967711,0.001785994,0.0001188256,0.9543916,0.0002245826],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001798949,0.9905302,0.003358367,0.0004896676,0.0001669102,0.004376157,0.00004073237,0.00001086359,0.0008472405],"genre_scores_gemma":[0.000212385,0.9580848,0.03950439,0.00005217225,0.00006344271,0.0003372657,0.00002497575,0.00003924141,0.001681395],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9542456,"threshold_uncertainty_score":0.9999097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3810675332135227,"score_gpt":0.5776063665176797,"score_spread":0.1965388333041571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}